LOCUS SIU00113.1 187 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN protein. ACCESSION LT708304-1526 PROTEIN_ID SIU00113.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB1510C" /note="Mb1510c, -, len: 187 aa. Equivalent to Rv1474c, len: 187 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 187 aa overlap). Probable transcription regulator, equivalent to AF0021|AF002133_1 transcriptional regulator from Mycobacterium avium strain GIR10 (82 aa), FASTA scores: opt: 490, E(): 6.7e-26, (92.5% identity in 80 aa overlap). Also similar to Q59431|UIDR_ECOLI UID OPERON REPRESSOR (GUS OPERON) from Escherichia coli (196 aa), FASTA scores: opt: 192, E(): 5.8e-06, (28.5% identity in 172 aa overlap). BELONGS TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS. Helix turn helix motif predicted at aa 33-54 (+3.40 SD). Protein product from Mb1510c detected using SWATH mass spectrometry. Mb1510c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing (TPM > 20)." /db_xref="GOA:A0A1R3Y0K1" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="UniProtKB/TrEMBL:A0A1R3Y0K1" BEGIN 1 MPKVSEDHLA ARRRQILDGA RRCFAEYGYD KATVRRLEQA IGMSRGAIFH HFRDKDALFF 61 ALAREDTERM AAVASREGLI GVMRDMLAAP DQFDWLATRL EIARKLRNDP DFSRGWAERS 121 AELAAATTDR LRRQKQANRV RDDVPSDVLR CYLDLVLDGL LARLASGEDP QRLAAVLDLV 181 ENSVRRS //