LOCUS       SIU00113.1               187 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            TRANSCRIPTIONAL REGULATORY PROTEIN protein.
ACCESSION   LT708304-1526
PROTEIN_ID  SIU00113.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB1510C"
                     /note="Mb1510c, -, len: 187 aa. Equivalent to Rv1474c,
                     len: 187 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100% identity in 187 aa overlap). Probable transcription
                     regulator, equivalent to AF0021|AF002133_1 transcriptional
                     regulator from Mycobacterium avium strain GIR10 (82 aa),
                     FASTA scores: opt: 490, E(): 6.7e-26, (92.5% identity in
                     80 aa overlap). Also similar to Q59431|UIDR_ECOLI UID
                     OPERON REPRESSOR (GUS OPERON) from Escherichia coli (196
                     aa), FASTA scores: opt: 192, E(): 5.8e-06, (28.5% identity
                     in 172 aa overlap). BELONGS TO THE TETR/ACRR FAMILY OF
                     TRANSCRIPTIONAL REGULATORS. Helix turn helix motif
                     predicted at aa 33-54 (+3.40 SD). Protein product from
                     Mb1510c detected using SWATH mass spectrometry. Mb1510c
                     found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:A0A1R3Y0K1"
                     /db_xref="InterPro:IPR001647"
                     /db_xref="InterPro:IPR009057"
                     /db_xref="InterPro:IPR036271"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y0K1"
BEGIN
        1 MPKVSEDHLA ARRRQILDGA RRCFAEYGYD KATVRRLEQA IGMSRGAIFH HFRDKDALFF
       61 ALAREDTERM AAVASREGLI GVMRDMLAAP DQFDWLATRL EIARKLRNDP DFSRGWAERS
      121 AELAAATTDR LRRQKQANRV RDDVPSDVLR CYLDLVLDGL LARLASGEDP QRLAAVLDLV
      181 ENSVRRS
//