LOCUS       SIU00054.1               154 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            RIBOFLAVIN SYNTHASE BETA CHAIN RIBH (6,7-dimethyl-8-ribityllumazine 
            synthase) (DMRL synthase) (Lumazine synthase) protein.
ACCESSION   LT708304-1467
PROTEIN_ID  SIU00054.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="ribH"
                     /locus_tag="BQ2027_MB1451"
                     /note="Mb1451, ribH, len: 154 aa. Equivalent to Rv1416,
                     len: 154 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100% identity in 154 aa overlap). Probable ribH,
                     riboflavin synthase beta chain (EC 2.5.1.9), similar to
                     many e.g. RISB_ECOLI|P25540 Escherichia coli (156 aa),
                     FASTA scores: opt: 330, E(): 1.8e-15, (44.1% identity in
                     145 aa overlap). Note alternative GTG start possible
                     overlapping the stop codon of Rv1415|MTCY21B4.33. BELONGS
                     TO THE DMRL SYNTHASE FAMILY. Protein product from Mb1451
                     detected using shotgun mass spectrometry and SWATH mass
                     spectrometry. Mb1451 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:P66035"
                     /db_xref="InterPro:IPR002180"
                     /db_xref="InterPro:IPR034964"
                     /db_xref="InterPro:IPR036467"
                     /db_xref="UniProtKB/Swiss-Prot:P66035"
BEGIN
        1 MPDLPSLDAS GVRLAIVASS WHGKICDALL DGARKVAAGC GLDDPTVVRV LGAIEIPVVA
       61 QELARNHDAV VALGVVIRGQ TPHFDYVCDA VTQGLTRVSL DSSTPIANGV LTTNTEEQAL
      121 DRAGLPTSAE DKGAQATVAA LATALTLREL RAHS
//