LOCUS       SIU00053.1               425 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            RIBOFLAVIN BIOSYNTHESIS PROTEIN RIBA2 : GTP cyclohydrolase
            II + 3,4-dihydroxy-2-butanone 4-phosphate synthase (DHBP
            synthase) protein.
ACCESSION   LT708304-1466
PROTEIN_ID  SIU00053.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="ribA2"
                     /locus_tag="BQ2027_MB1450"
                     /note="Mb1450, ribA2, len: 425 aa. Equivalent to Rv1415,
                     len: 425 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100% identity in 425 aa overlap). Probable ribA2,
                     Riboflavin biosynthesis protein (EC 3.5.4.25), similar to
                     many e.g. GCH2_BACSU|P17620 from Bacillus subtilis (398
                     aa), FASTA scores: opt: 1388, E(): 0, (55.4% identity in
                     399 aa overlap). Also similar to second Mycobacterium
                     tuberculosis gtp cyclohydrolase Rv1940|ribA1 (353 aa). IN
                     THE N-TERMINAL SECTION; BELONGS TO THE DHBP SYNTHASE
                     FAMILY. IN THE C-TERMINAL SECTION; BELONGS TO THE GTP
                     CYCLOHYDROLASE II FAMILY. Protein product from Mb1450
                     detected using shotgun mass spectrometry and SWATH mass
                     spectrometry. Mb1450 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:P0A5V1"
                     /db_xref="InterPro:IPR000422"
                     /db_xref="InterPro:IPR000926"
                     /db_xref="InterPro:IPR016299"
                     /db_xref="InterPro:IPR017945"
                     /db_xref="InterPro:IPR032677"
                     /db_xref="InterPro:IPR036144"
                     /db_xref="UniProtKB/Swiss-Prot:P0A5V1"
BEGIN
        1 MTRLDSVERA VADIAAGKAV IVIDDEDREN EGDLIFAAEK ATPEMVAFMV RYTSGYLCVP
       61 LDGAICDRLG LLPMYAVNQD KHGTAYTVTV DARNGIGTGI SASDRATTMR LLADPTSVAD
      121 DFTRPGHVVP LRAKDGGVLR RPGHTEAAVD LARMAGLQPA GAICEIVSQK DEGSMAHTDE
      181 LRVFADEHGL ALITIADLIE WRRKHEKHIE RVAEARIPTR HGEFRAIGYT SIYEDVEHVA
      241 LVRGEIAGPN ADGDDVLVRV HSECLTGDVF GSRRCDCGPQ LDAALAMVAR EGRGVVLYMR
      301 GHEGRGIGLM HKLQAYQLQD AGADTVDANL KLGLPADARD YGIGAQILVD LGVRSMRLLT
      361 NNPAKRVGLD GYGLHIIERV PLPVRANAEN IRYLMTKRDK LGHDLAGLDD FHESVHLPGE
      421 FGGAL
//