LOCUS       SIU00048.1               518 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 AMINOGLYCOSIDES/
            TETRACYCLINE-TRANSPORT INTEGRAL MEMBRANE PROTEIN protein.
ACCESSION   LT708304-1461
PROTEIN_ID  SIU00048.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB1445C"
                     /standard_name="P55"
                     /note="Mb1445c, -, len: 518 aa. Equivalent to Rv1410c,
                     len: 518 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100% identity in 518 aa overlap).
                     Aminoglycoside/tetracycline-transport integral membrane
                     protein (see citation below), member of major facilitator
                     superfamily (MFS), similar to others e.g.
                     AC22_STRCO|P46105 probable actinorhodin transporter from
                     Streptomyces coelicolor (578 aa), FASTA scores: opt: 442,
                     E(): 4.9e-21, (28.5% identity in 466 aa overlap); etc.
                     Contains PS00216 Sugar transport proteins signature 1.
                     Could be termed P55. Note that the Rv1410c-Rv1411c operon
                     seems transcribed from two promoters in M. bovis BCG (see
                     second citation). Protein product from Mb1445c detected
                     using shotgun mass spectrometry and SWATH mass
                     spectrometry. Mb1445c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:Q7U042"
                     /db_xref="InterPro:IPR001411"
                     /db_xref="InterPro:IPR005829"
                     /db_xref="InterPro:IPR011701"
                     /db_xref="InterPro:IPR020846"
                     /db_xref="InterPro:IPR036259"
                     /db_xref="UniProtKB/Swiss-Prot:Q7U042"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MRAGRRVAIS AGSLAVLLGA LDTYVVVTIM RDIMNSVGIP INQLHRITWI VTMYLLGYIA
       61 AMPLLGRASD RFGRKLMLQV SLAGFIIGSV VTALAGHFGD FHMLIAGRTI QGVASGALLP
      121 ITLALGADLW SQRNRAGVLG GIGAAQELGS VLGPLYGIFI VWLLHDWRDV FWINVPLTAI
      181 AMVMIHFSLP SHDRSTEPER VDLVGGLLLA LALGLAVIGL YNPNPDGKHV LPDYGAPLLV
      241 GALVAAVAFF GWERFARTRL IDPAGVHFRP FLSALGASVA AGAALMVTLV DVELFGQGVL
      301 QMDQAQAAGM LLWFLIALPI GAVTGGWIAT RAGDRAVAFA GLLIAAYGYW LISHWPVDLL
      361 ADRHNILGLF TVPAMHTDLV VAGLGLGLVI GPLSSATLRV VPSAQHGIAS AAVVVARMTG
      421 MLIGVAALSA WGLYRFNQIL AGLSAAIPPN ASLLERAAAI GARYQQAFAL MYGEIFTITA
      481 IVCVFGAVLG LLISGRKEHA DEPEVQEQPT LAPQVEPL
//