LOCUS       SIU00037.1               319 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 probable
            non lipolytic carboxylesterase nlhh protein.
ACCESSION   LT708304-1450
PROTEIN_ID  SIU00037.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="nlhh"
                     /locus_tag="BQ2027_MB1434C"
                     /note="Mb1434c, lipH, len: 319 aa. Equivalent to Rv1399c,
                     len: 319 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100% identity in 319 aa overlap). Possible LipH, lipase
                     (EC 3.1.-.-), most similar to G695278 lipase like enzyme
                     from Ralstonia eutropha (364 aa), FASTA scores: opt: 648,
                     E(): 4.4e-34, (37.3% identity in 327 aa ov erlap), similar
                     to Mycobacterium tuberculosis hypothetical lipases e.g.
                     Rv2284, Rv2485c, Rv1426c, etc. Protein product from
                     Mb1434c detected using SWATH mass spectrometry. Mb1434c
                     found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:A0A1R3XY93"
                     /db_xref="InterPro:IPR013094"
                     /db_xref="InterPro:IPR029058"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XY93"
BEGIN
        1 MTEPTVARPD IDPVLKMLLD TFPVTFTAAD GVEVARARLR QLKTPPELLP ELRIEERTVG
       61 YDGLTDIPVR VYWPPVVRDN LPVVVYYHGG GWSLGGLDTH DPVARAHAVG AQAIVVSVDY
      121 RLAPEHPYPA GIDDSWAALR WVGENAAELG GDPSRIAVAG DSAGGNISAV MAQLARDVGG
      181 PPLVFQLLWY PTTMADLSLP SFTENADAPI LDRDVIDAFL AWYVPGLDIS DHTMLPTTLA
      241 PGNADLSGLP PAFIGTAEHD PLRDDGACYA ELLTAAGVSV ELSNEPTMVH GYVNFALVVP
      301 AAAEATGRGL AALKRALHA
//