LOCUS SIU00037.1 319 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 probable non lipolytic carboxylesterase nlhh protein. ACCESSION LT708304-1450 PROTEIN_ID SIU00037.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="nlhh" /locus_tag="BQ2027_MB1434C" /note="Mb1434c, lipH, len: 319 aa. Equivalent to Rv1399c, len: 319 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 319 aa overlap). Possible LipH, lipase (EC 3.1.-.-), most similar to G695278 lipase like enzyme from Ralstonia eutropha (364 aa), FASTA scores: opt: 648, E(): 4.4e-34, (37.3% identity in 327 aa ov erlap), similar to Mycobacterium tuberculosis hypothetical lipases e.g. Rv2284, Rv2485c, Rv1426c, etc. Protein product from Mb1434c detected using SWATH mass spectrometry. Mb1434c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing (TPM > 20)." /db_xref="GOA:A0A1R3XY93" /db_xref="InterPro:IPR013094" /db_xref="InterPro:IPR029058" /db_xref="UniProtKB/TrEMBL:A0A1R3XY93" BEGIN 1 MTEPTVARPD IDPVLKMLLD TFPVTFTAAD GVEVARARLR QLKTPPELLP ELRIEERTVG 61 YDGLTDIPVR VYWPPVVRDN LPVVVYYHGG GWSLGGLDTH DPVARAHAVG AQAIVVSVDY 121 RLAPEHPYPA GIDDSWAALR WVGENAAELG GDPSRIAVAG DSAGGNISAV MAQLARDVGG 181 PPLVFQLLWY PTTMADLSLP SFTENADAPI LDRDVIDAFL AWYVPGLDIS DHTMLPTTLA 241 PGNADLSGLP PAFIGTAEHD PLRDDGACYA ELLTAAGVSV ELSNEPTMVH GYVNFALVVP 301 AAAEATGRGL AALKRALHA //