LOCUS       SIU00027.1               208 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            GUANYLATE KINASE GMK protein.
ACCESSION   LT708304-1440
PROTEIN_ID  SIU00027.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="gmk"
                     /locus_tag="BQ2027_MB1424"
                     /note="Mb1424, gmk, len: 208 aa. Equivalent to Rv1389,
                     len: 208 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100% identity in 208 aa overlap). Probable gmk, guanylate
                     kinase (EC 2.7.4.8), similar to e.g. KGUA_ECOLI|P24234
                     guanylate kinase from Escherichia coli (207 aa), FASTA
                     scores: opt: 424, E(): 6.6e-20, (35.9% identity in 184 aa
                     overlap). Contains PS00017 ATP/GTP-binding site motif A
                     (P-loop), PS00856 Guanylate kinase signature. BELONGS TO
                     THE GUANYLATE KINASE FAMILY. Protein product from Mb1424
                     detected using SWATH mass spectrometry. Mb1424 found to be
                     expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
                     /db_xref="GOA:P0A5I5"
                     /db_xref="InterPro:IPR008144"
                     /db_xref="InterPro:IPR008145"
                     /db_xref="InterPro:IPR017665"
                     /db_xref="InterPro:IPR020590"
                     /db_xref="InterPro:IPR027417"
                     /db_xref="UniProtKB/Swiss-Prot:P0A5I5"
BEGIN
        1 MSVGEGPDTK PTARGQPAAV GRVVVLSGPS AVGKSTVVRC LRERIPNLHF SVSATTRAPR
       61 PGEVDGVDYH FIDPTRFQQL IDQGELLEWA EIHGGLHRSG TLAQPVRAAA ATGVPVLIEV
      121 DLAGARAIKK TMPEAVTVFL APPSWQDLQA RLIGRGTETA DVIQRRLDTA RIELAAQGDF
      181 DKVVVNRRLE SACAELVSLL VGTAPGSP
//