LOCUS       SIU00019.1               430 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            DIHYDROOROTASE PYRC (DHOase) protein.
ACCESSION   LT708304-1432
PROTEIN_ID  SIU00019.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="pyrC"
                     /locus_tag="BQ2027_MB1416"
                     /note="Mb1416, pyrC, len: 430 aa. Equivalent to Rv1381,
                     len: 430 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.8% identity in 430 aa overlap). Probable pyrC,
                     dihydroorotase (EC 3.5.2.3), similar to many e.g.
                     PYRC_BACCL|P46538 (40.5% identity in 395 aa overlap).
                     Contains PS00483 Dihydroorotase signature 2. BELONGS TO
                     THE DHOASE FAMILY. SUBFAMILY 2. Protein product from
                     Mb1416 detected using shotgun mass spectrometry and SWATH
                     mass spectrometry. Mb1416 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:Q7U057"
                     /db_xref="InterPro:IPR002195"
                     /db_xref="InterPro:IPR004722"
                     /db_xref="InterPro:IPR006680"
                     /db_xref="InterPro:IPR011059"
                     /db_xref="InterPro:IPR032466"
                     /db_xref="UniProtKB/Swiss-Prot:Q7U057"
BEGIN
        1 MSVLIRGVRP YGEGERVDVL VDDGQIAQIG PDLAIPDTAD VIDATGHVLL PGFVDLHTHL
       61 REPGREYAED IETGSAAAAL GGYTAVFAMA NTNPVADSPV VTDHVWHRGQ QVGLVDVHPV
      121 GAVTVGLAGA ELTEMGMMNA GAAQVRMFSD DGVCVHDPLI MRRALEYATG LGVLIAQHAE
      181 EPRLTVGAFA HEGPMAARLG LAGWPRAAEE SIVARDALLA RDAGARVHIC HASAAGTVEI
      241 LKWAKDQGIS ITAEVTPHHL LLDDARLASY DGVNRVNPPL REASDAVALR QALADGIIDC
      301 VATDHAPHAE HEKCVEFAAA RPGMLGLQTA LSVVVQTMVA PGLLSWRDIA RVMSENPACI
      361 ARLPDQGRPL EVGEPANLTV VDPDATWTVT GADLASRSAN TPFESMSLPA TVTATLLRGK
      421 VTARDGKIRA
//