LOCUS SIU00019.1 430 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE DIHYDROOROTASE PYRC (DHOase) protein. ACCESSION LT708304-1432 PROTEIN_ID SIU00019.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="pyrC" /locus_tag="BQ2027_MB1416" /note="Mb1416, pyrC, len: 430 aa. Equivalent to Rv1381, len: 430 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 430 aa overlap). Probable pyrC, dihydroorotase (EC 3.5.2.3), similar to many e.g. PYRC_BACCL|P46538 (40.5% identity in 395 aa overlap). Contains PS00483 Dihydroorotase signature 2. BELONGS TO THE DHOASE FAMILY. SUBFAMILY 2. Protein product from Mb1416 detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb1416 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:Q7U057" /db_xref="InterPro:IPR002195" /db_xref="InterPro:IPR004722" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="UniProtKB/Swiss-Prot:Q7U057" BEGIN 1 MSVLIRGVRP YGEGERVDVL VDDGQIAQIG PDLAIPDTAD VIDATGHVLL PGFVDLHTHL 61 REPGREYAED IETGSAAAAL GGYTAVFAMA NTNPVADSPV VTDHVWHRGQ QVGLVDVHPV 121 GAVTVGLAGA ELTEMGMMNA GAAQVRMFSD DGVCVHDPLI MRRALEYATG LGVLIAQHAE 181 EPRLTVGAFA HEGPMAARLG LAGWPRAAEE SIVARDALLA RDAGARVHIC HASAAGTVEI 241 LKWAKDQGIS ITAEVTPHHL LLDDARLASY DGVNRVNPPL REASDAVALR QALADGIIDC 301 VATDHAPHAE HEKCVEFAAA RPGMLGLQTA LSVVVQTMVA PGLLSWRDIA RVMSENPACI 361 ARLPDQGRPL EVGEPANLTV VDPDATWTVT GADLASRSAN TPFESMSLPA TVTATLLRGK 421 VTARDGKIRA //