LOCUS       SIU00008.1               317 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            CONSERVED MEMBRANE PROTEIN protein.
ACCESSION   LT708304-1420
PROTEIN_ID  SIU00008.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB1404"
                     /note="Mb1404 found to be expressed during exponential
                     growth in Sauton's minimal media by
                     RNA-sequencing.,Mb1404, -, len: 317 aa. Similar to 5' end
                     of Rv1371, len: 489 aa, from Mycobacterium tuberculosis
                     strain H37Rv, (90.9% identity in 166 aa overlap). Probable
                     membrane protein. Weak similarity to delta 5 fatty acid
                     desaturases e.g. AB022097|AB022097_1 Dictyostelium
                     discoideum (467 aa), FASTA score: opt: 173, E(): 0.00052,
                     (22.4% identity in 438 aa overlap); and Homo sapiens.
                     REMARK-M.bovis-M.tuberculosis: In Mycobacterium
                     tuberculosis strain H37Rv, Rv1371 exists as a single gene.
                     In Mycobacterium bovis, a frameshift due to a single base
                     insertion (*-a) splits Rv1371 into 2 parts, Mb1404 and
                     Mb1405, with the latter being the more likely product."
                     /db_xref="InterPro:IPR001199"
                     /db_xref="InterPro:IPR036400"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XY65"
BEGIN
        1 MTNDLPDVRE RDGGPRPAPP AGGPRLSDVW VYNGRAYDLS EWISKHPGGA FFIGRTKNRD
       61 ITAIVKSYHR DPAIVERILQ RRYALGRDAT PRDIHPKHNA PAFLFKDDFN SWRDTPKYRF
      121 DDPNDLLHRV KARLAEPALA ARIKRMDTLY QRHRCSTGRG LFRGSGCAVG GTELDAAVGL
      181 RDCDGSAAQF VGRVRSLRTA PRATRPQPGF QQCLRSQLCG LVLSHRRRTH PAAPPVYPER
      241 GGHQEERVHD DDAATVVVSR SRTYDSQIWP HAQRHGDPDR RRLQDHAQGR CRGILRKLAC
      301 RASTLPWIGR GALASGE
//