LOCUS       SIT99999.1               396 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 ppe
            family protein ppe19 protein.
ACCESSION   LT708304-1411
PROTEIN_ID  SIT99999.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="PPE19"
                     /locus_tag="BQ2027_MB1396C"
                     /standard_name="mtb39b"
                     /note="Mb1396c, PPE19, len: 396 aa. Similar to Rv1361c,
                     len: 396 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (92.9% identity in 396 aa overlap). PPE19 (alternate gene
                     name: mtb39b). Member of the Mycobacterium tuberculosis
                     PPE family of glycine-rich proteins, highly similar to
                     many e.g. Rv1196|MTCI364.08|PPE18, FASTA scores: E(): 0,
                     (84.9% identity in 397 aa overlap); MTCY274.23c (42.3%
                     identity in 416 aa overlap); etc. Contains PS00501 Signal
                     peptidases I serine active site. Note that expression of
                     Rv1361c was demonstrated in lysates by immunodetection
                     (see first citation below). REMARK-M.bovis-M.tuberculosis:
                     In Mycobacterium bovis, the PPE19 gene contains nine
                     substitutions compared to Mycobacterium tuberculosis
                     strain H37Rv. Mb1396c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="InterPro:IPR000030"
                     /db_xref="InterPro:IPR022171"
                     /db_xref="InterPro:IPR038332"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XY45"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MVDFGALPPE INSARMYAGP GSASLVAAAQ MWDSVASDLF SAASAFQSVV WGLTVGSWIG
       61 SSAGLMVAAA SPYVAWMSVT AGQAELTAAQ VRVAAAAYET AYGLTVPPPV IAENRAELMI
      121 LIATNLLGQN TPAIAVNEAE YGEMWAQDAA AMFGYAAATA TATATLLPFE EAPEMTSAGG
      181 LLEQAAAVEE ASDTAAANQL MNNVPQALQQ LAQPTQGTTP SSKLGGLWKT VSPHLSPISN
      241 IVSMLNNHVS MTNSGVSMTN TLHSMLKGFA PAAAQAVETA AQNGVQAMSS LGSQLGSSLG
      301 SSGLGAGVAA NLGRAASVGS LSVPPAWAAA NQAVTPAARA LPLTSLTSAA QTAPGHMLGG
      361 LPLGQLTNSG GGFGGVSNAL RMPPRAYVMP RVPAAG
//