LOCUS SIT99999.1 396 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 ppe family protein ppe19 protein. ACCESSION LT708304-1411 PROTEIN_ID SIT99999.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="PPE19" /locus_tag="BQ2027_MB1396C" /standard_name="mtb39b" /note="Mb1396c, PPE19, len: 396 aa. Similar to Rv1361c, len: 396 aa, from Mycobacterium tuberculosis strain H37Rv, (92.9% identity in 396 aa overlap). PPE19 (alternate gene name: mtb39b). Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, highly similar to many e.g. Rv1196|MTCI364.08|PPE18, FASTA scores: E(): 0, (84.9% identity in 397 aa overlap); MTCY274.23c (42.3% identity in 416 aa overlap); etc. Contains PS00501 Signal peptidases I serine active site. Note that expression of Rv1361c was demonstrated in lysates by immunodetection (see first citation below). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, the PPE19 gene contains nine substitutions compared to Mycobacterium tuberculosis strain H37Rv. Mb1396c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="InterPro:IPR000030" /db_xref="InterPro:IPR022171" /db_xref="InterPro:IPR038332" /db_xref="UniProtKB/TrEMBL:A0A1R3XY45" /experiment="experimental evidence, no additional details recorded" BEGIN 1 MVDFGALPPE INSARMYAGP GSASLVAAAQ MWDSVASDLF SAASAFQSVV WGLTVGSWIG 61 SSAGLMVAAA SPYVAWMSVT AGQAELTAAQ VRVAAAAYET AYGLTVPPPV IAENRAELMI 121 LIATNLLGQN TPAIAVNEAE YGEMWAQDAA AMFGYAAATA TATATLLPFE EAPEMTSAGG 181 LLEQAAAVEE ASDTAAANQL MNNVPQALQQ LAQPTQGTTP SSKLGGLWKT VSPHLSPISN 241 IVSMLNNHVS MTNSGVSMTN TLHSMLKGFA PAAAQAVETA AQNGVQAMSS LGSQLGSSLG 301 SSGLGAGVAA NLGRAASVGS LSVPPAWAAA NQAVTPAARA LPLTSLTSAA QTAPGHMLGG 361 LPLGQLTNSG GGFGGVSNAL RMPPRAYVMP RVPAAG //