LOCUS SIT99986.1 859 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 iron- regulated transporter irta protein. ACCESSION LT708304-1398 PROTEIN_ID SIT99986.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="irta" /locus_tag="BQ2027_MB1383" /note="Mb1383, -, len: 859 aa. Equivalent to Rv1348, len: 859 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 859 aa overlap). Probable drugs-transport transmembrane protein ATP binding protein ABC transporter (see citation below), similar to HMT1_SCHPO|Q02592 heavy metal tolerance protein precursor from Schizosaccharomyces pombe (830 aa), FASTA scores: opt: 806, E(): 5.1e-39, (32.9% identity in 504 aa overlap); etc. Also similar to MTCY02B10.13 from Mycobacterium tuberculosis, FASTA score: (31.9% identity in 576 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00211 ABC transporters family signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Protein product from Mb1383 detected using SWATH mass spectrometry. Mb1383 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:P63392" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR007037" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR013113" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="InterPro:IPR039261" /db_xref="UniProtKB/Swiss-Prot:P63392" BEGIN 1 MARGLQGVML RSFGARDHTA TVIETISIAP HFVRVRMVSP TLFQDAEAEP AAWLRFWFPD 61 PNGSNTEFQR AYTISEADPA AGRFAVDVVL HDPAGPASSW ARTVKPGATI AVMSLMGSSR 121 FDVPEEQPAG YLLIGDSASI PGMNGIIETV PNDVPIEMYL EQHDDNDTLI PLAKHPRLRV 181 RWVMRRDEKS LAEAIENRDW SDWYAWATPE AAALKCVRVR LRDEFGFPKS EIHAQAYWNA 241 GRAMGTHRAT EPAATEPEVG AAPQPESAVP APARGSWRAQ AASRLLAPLK LPLVLSGVLA 301 ALVTLAQLAP FVLLVELSRL LVSGAGAHRL FTVGFAAVGL LGTGALLAAA LTLWLHVIDA 361 RFARALRLRL LSKLSRLPLG WFTSRGSGSI KKLVTDDTLA LHYLVTHAVP DAVAAVVAPV 421 GVLVYLFVVD WRVALVLFGP VLVYLTITSS LTIQSGPRIV QAQRWAEKMN GEAGSYLEGQ 481 PVIRVFGAAS SSFRRRLDEY IGFLVAWQRP LAGKKTLMDL ATRPATFLWL IAATGTLLVA 541 THRMDPVNLL PFMFLGTTFG ARLLGIAYGL GGLRTGLLAA RHLQVTLDET ELAVREHPRE 601 PLDGEAPATV VFDHVTFGYR PGVPVIQDVS LTLRPGTVTA LVGPSGSGKS TLATLLARFH 661 DVERGAIRVG GQDIRSLAAD ELYTRVGFVL QEAQLVHGTA AENIALAVPD APAEQVQVAA 721 REAQIHDRVL RLPDGYDTVL GANSGLSGGE RQRLTIARAI LGDTPVLILD EATAFADPES 781 EYLVQQALNR LTRDRTVLVI AHRLHTITRA DQIVVLDHGR IVERGTHEEL LAAGGRYCRL 841 WDTGQGSRVA VAAAQDGTR //