LOCUS       SIT99968.1               448 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 nicotinic
            acid phosphoribosyltransferase pncB1 protein.
ACCESSION   LT708304-1380
PROTEIN_ID  SIT99968.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="pncB1"
                     /locus_tag="BQ2027_MB1365C"
                     /note="Mb1365c, -, len: 448 aa. Equivalent to Rv1330c,
                     len: 448 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.6% identity in 448 aa overlap). Conserved hypothetical
                     protein, similar to others and also several nicotinate
                     phosphoribosyltransferases e.g. O32090 YUEK PROTEIN from
                     Bacillus subtilis (490 aa), FASTA scores: E(): 8.6e-22,
                     (37.9% identity in 369 aa overlap). Also similar to M.
                     tuberculosis Rv0573c|MTV039.11c (38.0% identity in 437 aa
                     overlap). Start changed since original submission based on
                     similarity; previous start at position 1500740 (-61 aa).
                     Protein product from Mb1365c detected using SWATH mass
                     spectrometry. Mb1365c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3XY18"
                     /db_xref="InterPro:IPR002638"
                     /db_xref="InterPro:IPR006405"
                     /db_xref="InterPro:IPR007229"
                     /db_xref="InterPro:IPR013785"
                     /db_xref="InterPro:IPR036068"
                     /db_xref="InterPro:IPR040727"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XY18"
BEGIN
        1 MGPPPAARRR EGEPDNQDPA GLLTDKYELT MLAAALRDGS ANRPTTFEVF ARRLPTGRRY
       61 GVVAGTGRLL EALPQFRFDA DACELLAQFL DPATVRYLRE FRFRGDIDGY AEGELYFPGS
      121 PVLSVRGSFA ECVLLETLVL SIFNHDTAIA SAAARMVSAA GGRPLIEMGS RRTHERAAVA
      181 AARAAYIAGF AASSNLAAQR RYGVPAHGTA AHAFTMLHAQ HGGPTELAER AAFRAQVEAL
      241 GPGTTLLVDT YDVTTGVANA VAAAGAELGA IRIDSGELGV LARQAREQLD RLGATRTRIV
      301 VSGDLDEFSI AALRGEPVDS YGVGTSLVTG SGAPTANMVY KLVEVDGVPV QKRSSYKKSP
      361 GGRKEALRRS RATGTITEEL VHPAGRPPVI VEPHRVLTLP LVRAGQPVAD TSLAAARQLV
      421 ASGLRSLPAD GLKLAPGEPA IPTRTIPA
//