LOCUS       SIT99957.1               567 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE
            ADENYLATE CYCLASE (ATP PYROPHOSPHATE-LYASE) (ADENYLYL
            CYCLASE) protein.
ACCESSION   LT708304-1369
PROTEIN_ID  SIT99957.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB1354C"
                     /note="Mb1354c, -, len: 567 aa. Equivalent to Rv1320c,
                     len: 567 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.8% identity in 567 aa overlap). Possible adenylate
                     cyclase (EC 4.6.1.1) (see second citation below). Some
                     similarity at the C-terminus to CYAA_RHIME|P19485
                     adenylate cyclase from Rhizobium meliloti (193 aa), FASTA
                     scores: opt: 277, E(): 2e-12, (34.0% identity in 156 aa
                     overlap); similar to other mycbacterium tuberculosis
                     putative adenylate cyclases e.g. Rv1318c|MTCY130.03c (541
                     aa), FASTA scores: opt: 2423, E(): 0, (68.7% identity in
                     534 aa overlap); Rv1319c|MTCY130.04c (535 aa), FASTA
                     scores: opt: 2354, E(): 0, (66.3% identity in 534 aa
                     overlap). N-terminus is hydrophobic. BELONGS TO ADENYLYL
                     CYCLASE CLASS-3 FAMILY. Protein product from Mb1354c
                     detected using SWATH mass spectrometry. Mb1354c found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
                     /db_xref="GOA:P59972"
                     /db_xref="InterPro:IPR001054"
                     /db_xref="InterPro:IPR003660"
                     /db_xref="InterPro:IPR029787"
                     /db_xref="UniProtKB/Swiss-Prot:P59972"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MPSEKATTRH LPGAVETLSP RTGRRPETPA YGSWLLGRVS ESPRMRRVRI QGMLTVAILV
       61 TNVIGLIVGA MLLTVAFPKP SVILDAPHWV SFGIVPGYCV LAFILGTYWL TRQTARALRW
      121 AIEERTPSHD EARSAFLVPL RVALAVLFLW GAAAALWTII YGLANRLFIP RFLFSMGVIG
      181 VVAATSCYLL TEFALRPMAA QALEVGATPR SLVRGIVGRT MLVWLLCSGV PNVGVALTAI
      241 FDDTFWELSN DQFMITVLIL WAPLLIFGFI LMWILAWLTA TPVRVVREAL NRVEQGDLSG
      301 DLVVFDGTEL GELQRGFNRM VEGLRERERV RDLFGRHVGR EVAAAAERER PKLGGEERHV
      361 AVVFVDIVGS TQLVTSRPAA EVVMLLNRFF TVIVDEVNHH RGLVNKFQGD ASLAVFGAPN
      421 RLSHPEDAAL ATARAIADRL ASEMPECQAG IGVAAGQVVA GNVGAHERFE YTVIGEPVNE
      481 AARLCELAKS YPSRLLASSQ TLRGASENEC ARWSLGETVT LRGHDQPIRL ASPVQQLQMP
      541 AQSADIVGGA LGDHQTHTIY RGAHPTD
//