LOCUS       SIT99956.1               535 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE
            ADENYLATE CYCLASE (ATP PYROPHOSPHATE-LYASE) (ADENYLYL
            CYCLASE) protein.
ACCESSION   LT708304-1368
PROTEIN_ID  SIT99956.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB1353C"
                     /note="Mb1353c, -, len: 535 aa. Equivalent to Rv1319c,
                     len: 535 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100% identity in 535 aa overlap). Possible adenylate
                     cyclase (EC 4.6.1.1). Some similarity at the C-terminus to
                     CYAA_RHIME|P19485 adenylate cyclase from Rhizobium
                     meliloti (193 aa), FASTA scores: opt: 254, E(): 2.4e-10,
                     (33.3% identity in 144 aa overlap); similar to other
                     mycbacterium tuberculosis putative adenylate cyclases e.g.
                     Rv1318c|MTCY130.03c (541 aa), FASTA scores: opt: 2505,
                     E(): 0, (71.0% identity in 534 aa overlap);
                     Rv1320c|MTCY130.05c (567 aa), FASTA scores: opt: 2354,
                     E(): 0, (66.3% identity in 534 aa overlap). N-terminus is
                     hydrophobic. BELONGS TO ADENYLYL CYCLASE CLASS-3 FAMILY.
                     Protein product from Mb1353c detected using SWATH mass
                     spectrometry. Mb1353c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:P0A4Y3"
                     /db_xref="InterPro:IPR001054"
                     /db_xref="InterPro:IPR003660"
                     /db_xref="InterPro:IPR029787"
                     /db_xref="UniProtKB/Swiss-Prot:P0A4Y3"
BEGIN
        1 MPAKKTMAQR LGQALETMTR QCGQLPETPA YGSWLLGRVS ESPSRRWVRI KRIVTVYIMT
       61 ANLTGIVVAL LVVTFAFPVP SIYTDAPWWV TFGVAPAYAT LALAIGTYWI TTRIVRASIR
      121 WAIEERAPSQ ADGRNTLLLP FRVAAVHLIL WDIGGALLAT LYGLANRVFV TIILFSVTIC
      181 GVLVATNCYL FTEFALRPVA AKALEAGRPP RRFAPGIMGR TMTVWSLGSG VPVTGIATTA
      241 LYVLLVHNLT ETQLASAVLI LSITTLIFGF LVMWILAWLT AAPVRVVRAA LKRVEQGDLR
      301 GDLVVFDGTE LGELQRGFNA MVNGLRERER VRDLFGRHVG REVAAAAERE RPQLGGEDRH
      361 AAVVFVDIVG STQLVDNQPA AHVVKLLNRF FAIVVNEVDR HHGLINKFAG DAALAIFGAP
      421 NRLDRPEDAA LAAARAIADR LANEMPEVQA GIGVAAGQIV AGNVGAKQRF EYTVVGKPVN
      481 QAARLCELAK SHPARLLASS DTLHAASETE RAHWSLGETV TLRGHEQPTR LAVPT
//