LOCUS       SIT99955.1               541 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE
            ADENYLATE CYCLASE (ATP PYROPHOSPHATE-LYASE) (ADENYLYL
            CYCLASE) protein.
ACCESSION   LT708304-1367
PROTEIN_ID  SIT99955.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB1352C"
                     /note="Mb1352c, -, len: 541 aa. Equivalent to Rv1318c,
                     len: 541 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100% identity in 541 aa overlap). Possible adenylate
                     cyclase (EC 4.6.1.1). Some similarity at the c-terminus to
                     CYAA_RHIME|P19485 adenylate cyclase from Rhizobium
                     meliloti (193 aa), FASTA scores, opt: 270, E(): 2.5e-11,
                     (28.8% identity in 184 aa overlap); similar to other
                     mycbacterium tuberculosis putative adenylate cyclases e.g.
                     Rv1319c|MTCY130.04c (535 aa), FASTA scores: opt: 2505,
                     E(): 0, (71.0% identity in 534 aa overlap), also similar
                     to Rv1320c|MTCY130.05c (567 aa), FASTA scores, opt: 2423,
                     E(): 0, (68.7% identity in 534 aa overlap). N-terminus is
                     hydrophobic. BELONGS TO ADENYLYL CYCLASE CLASS-3 FAMILY.
                     Mb1352c found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:P63528"
                     /db_xref="InterPro:IPR001054"
                     /db_xref="InterPro:IPR003660"
                     /db_xref="InterPro:IPR029787"
                     /db_xref="UniProtKB/Swiss-Prot:P63528"
BEGIN
        1 MSAKKSTAQR LGRVLETVTR QSGRLPETPA YGSWLLGRVS ESQRRRRVRI QVMLTALVVT
       61 ANLLGIGVAL LLVTIAIPEP SIVRDTPRWL TFGVVPGYVL LALALGSYAL TRQTVQALRW
      121 AIEGRKPTRE EERRTFLAPW RVAVGHLMFW GVGTALLTTL YGLINNAFIP RFLFAVSFCG
      181 VLVATATYLH TEFALRPFAA QALEAGPPPR RLAPGILGRT MVVWLLGSGV PVVGIALMAM
      241 FEMVLLNLTR MQFATGVLII SMVTLVFGFI LMWILAWLTA TPVRVVRAAL RRVERGELRT
      301 NLVVFDGTEL GELQRGFNAM VAGLRERERV RDLFGRHVGR EVAAAAERER SKLGGEERHV
      361 AVVFIDIVGS TQLVTSRPPA DVVKLLNKFF AIVVDEVDRH HGLVNKFEGD ASLTIFGAPN
      421 RLPCPEDKAL AAARAIADRL VNEMPECQAG IGVAAGQVIA GNVGARERFE YTVIGEPVNE
      481 AARLCELAKS RPGKLLASAQ AVDAASEEER ARWSLGRHVK LRGHDQPVRL AKPVGLTKPR
      541 R
//