LOCUS SIT99955.1 541 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE ADENYLATE CYCLASE (ATP PYROPHOSPHATE-LYASE) (ADENYLYL CYCLASE) protein. ACCESSION LT708304-1367 PROTEIN_ID SIT99955.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB1352C" /note="Mb1352c, -, len: 541 aa. Equivalent to Rv1318c, len: 541 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 541 aa overlap). Possible adenylate cyclase (EC 4.6.1.1). Some similarity at the c-terminus to CYAA_RHIME|P19485 adenylate cyclase from Rhizobium meliloti (193 aa), FASTA scores, opt: 270, E(): 2.5e-11, (28.8% identity in 184 aa overlap); similar to other mycbacterium tuberculosis putative adenylate cyclases e.g. Rv1319c|MTCY130.04c (535 aa), FASTA scores: opt: 2505, E(): 0, (71.0% identity in 534 aa overlap), also similar to Rv1320c|MTCY130.05c (567 aa), FASTA scores, opt: 2423, E(): 0, (68.7% identity in 534 aa overlap). N-terminus is hydrophobic. BELONGS TO ADENYLYL CYCLASE CLASS-3 FAMILY. Mb1352c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing (TPM > 20)." /db_xref="GOA:P63528" /db_xref="InterPro:IPR001054" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR029787" /db_xref="UniProtKB/Swiss-Prot:P63528" BEGIN 1 MSAKKSTAQR LGRVLETVTR QSGRLPETPA YGSWLLGRVS ESQRRRRVRI QVMLTALVVT 61 ANLLGIGVAL LLVTIAIPEP SIVRDTPRWL TFGVVPGYVL LALALGSYAL TRQTVQALRW 121 AIEGRKPTRE EERRTFLAPW RVAVGHLMFW GVGTALLTTL YGLINNAFIP RFLFAVSFCG 181 VLVATATYLH TEFALRPFAA QALEAGPPPR RLAPGILGRT MVVWLLGSGV PVVGIALMAM 241 FEMVLLNLTR MQFATGVLII SMVTLVFGFI LMWILAWLTA TPVRVVRAAL RRVERGELRT 301 NLVVFDGTEL GELQRGFNAM VAGLRERERV RDLFGRHVGR EVAAAAERER SKLGGEERHV 361 AVVFIDIVGS TQLVTSRPPA DVVKLLNKFF AIVVDEVDRH HGLVNKFEGD ASLTIFGAPN 421 RLPCPEDKAL AAARAIADRL VNEMPECQAG IGVAAGQVIA GNVGARERFE YTVIGEPVNE 481 AARLCELAKS RPGKLLASAQ AVDAASEEER ARWSLGRHVK LRGHDQPVRL AKPVGLTKPR 541 R //