LOCUS SIT99949.1 205 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE TRANSPOSASE [FIRST PART] protein. ACCESSION LT708304-1361 PROTEIN_ID SIT99949.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB1346C" /note="Mb1346c, -, len: 205 aa. Equivalent to 5' end of Rv1313c, len: 444 aa, from Mycobacterium tuberculosis strain H37Rv, (99.5% identity in 195 aa overlap). Possible IS1557 transposase, similar to several transposases e.g. U57649|DBU57649 ORF1 from dibenzofuran-degrading bacterium DPO360 (163 aa), FASTA scores: opt: 767, E(): 0, (67.3% identity in 168 aa overlap); TNPA_BORPA|Q06126 transposase for insertion sequence element IS1001 from Bordetella parapertussis (406 aa), FASTA scores: opt: 254, E(): 3.3e-10, (24.9% identity in 402 aa overlap). Also similar to putative Mycobacterium tuberculosis transposases, Rv3798 and Rv0741. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1313c exists as a single gene. In Mycobacterium bovis, a frameshift due to a 12 bp to 1 bp substitution (cttgtcgtggcc-t) splits Rv1313c into 2 parts, Mb1345c and Mb1346c. Mb1346c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing (TPM > 20)." /db_xref="InterPro:IPR002560" /db_xref="InterPro:IPR029261" /db_xref="InterPro:IPR032877" /db_xref="UniProtKB/TrEMBL:A0A0G2QBZ2" BEGIN 1 MRNVRLFRAL LGVDKRTVIE DIEFEEDDAG DGARVIARVR PRSAVLRRCG RCGRKASWYD 61 RGAGLRQWRS LDWGTVEVFL EAEAPRVNCP THGPTVVAVP WARHHAGHTY AFDDTVAWLA 121 VACSKTAVCE LMRIAWRTVG AIVARVWADT EKRIDRFANL RRIGIDEISY KRHHRYLTVV 181 VDHDSGRLVW AAPSHPGLVL RCPGR //