LOCUS       SIT99947.1               144 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 CONSERVED
            HYPOTHETICAL SECRETED PROTEIN protein.
ACCESSION   LT708304-1359
PROTEIN_ID  SIT99947.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB1344"
                     /note="Mb1344, -, len: 144 aa. Equivalent to Rv1312, len:
                     147 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.3% identity in 142 aa overlap). Conserved hypothetical
                     secreted protein with potential N-terminal signal
                     sequence. Highly similar to P53432|Y02W_MYCLE hypothetical
                     Mycobacterium leprae protein (147 aa), FASTA score: opt:
                     884, E(): 0, (88.4% identity in 147 aa overlap).
                     N-terminus hydrophobic. REMARK-M.bovis-M.tuberculosis: In
                     Mycobacterium bovis, a 2 bp deletion (cg-*) at the 3' end
                     leads to a slightly shorter product compared to
                     Mycobacterium tuberculosis strain H37Rv (144 aa versus 147
                     aa). Protein product from Mb1344 detected using shotgun
                     mass spectrometry and SWATH mass spectrometry. Mb1344
                     found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:A0A1R3XXZ8"
                     /db_xref="InterPro:IPR019675"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XXZ8"
BEGIN
        1 MSVPMIGMVV LVVVLGLAVL ALSYRLWKLR QGGTAGIMRD IPAVGGHGWR HGVIRYRGGE
       61 AAFYRLSSLR LWPDRRLSRR GVEIISRRAP RGDEFDIMTD EIVVVELCDS TQDRRVGYEI
      121 ALDRGALTAF LSWLESRPSP RAPP
//