LOCUS SIT99945.1 486 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE ATP SYNTHASE BETA CHAIN ATPD protein. ACCESSION LT708304-1357 PROTEIN_ID SIT99945.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="atpD" /locus_tag="BQ2027_MB1342" /note="Mb1342, atpD, len: 486 aa. Equivalent to Rv1310, len: 486 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 486 aa overlap). Probable atpD, ATP synthase beta chain (EC 3.6.3.14), highly similar to ATPB_MYCLE|P45823 Mycobacterium leprae (485 aa), FASTA score: opt: 2916, E(): 0, (92.6% identity in 484 aa overlap). Contains PS00017 ATP/GTP-binding site motif A, PS00152 ATP synthase alpha and beta subunits signature. SUBUNIT: F-TYPE ATPASES HAVE 2 COMPONENTS, CF(1) - THE CATALYTIC CORE - AND CF(0) - THE MEMBRANE PROTON CHANNEL. CF(1) HAS FIVE SUBUNITS: ALPHA(3), BETA(3), GAMMA(1), DELTA(1), EPSILON(1). CF(0) HAS THREE MAIN SUBUNITS: A, B AND C. BELONGS TO THE ATPASE ALPHA/BETA CHAINS FAMILY. Protein product from Mb1342 detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb1342 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing (TPM > 20)." /db_xref="GOA:P63678" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004100" /db_xref="InterPro:IPR005722" /db_xref="InterPro:IPR020003" /db_xref="InterPro:IPR024034" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036121" /db_xref="UniProtKB/Swiss-Prot:P63678" /experiment="experimental evidence, no additional details recorded" BEGIN 1 MTTTAEKTDR PGKPGSSDTS GRVVRVTGPV VDVEFPRGSI PELFNALHAE ITFESLAKTL 61 TLEVAQHLGD NLVRTISLQP TDGLVRGVEV IDTGRSISVP VGEGVKGHVF NALGDCLDEP 121 GYGEKFEHWS IHRKPPAFEE LEPRTEMLET GLKVVDLLTP YVRGGKIALF GGAGVGKTVL 181 IQEMINRIAR NFGGTSVFAG VGERTREGND LWVELAEANV LKDTALVFGQ MDEPPGTRMR 241 VALSALTMAE WFRDEQGQDV LLFIDNIFRF TQAGSEVSTL LGRMPSAVGY QPTLADEMGE 301 LQERITSTRG RSITSMQAVY VPADDYTDPA PATTFAHLDA TTELSRAVFS KGIFPAVDPL 361 ASSSTILDPS VVGDEHYRVA QEVIRILQRY KDLQDIIAIL GIDELSEEDK QLVNRARRIE 421 RFLSQNMMAA EQFTGQPGST VPVKETIEAF DRLCKGDFDH VPEQAFFLIG GLDDLAKKAE 481 SLGAKL //