LOCUS       SIT99945.1               486 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            ATP SYNTHASE BETA CHAIN ATPD protein.
ACCESSION   LT708304-1357
PROTEIN_ID  SIT99945.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="atpD"
                     /locus_tag="BQ2027_MB1342"
                     /note="Mb1342, atpD, len: 486 aa. Equivalent to Rv1310,
                     len: 486 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100% identity in 486 aa overlap). Probable atpD, ATP
                     synthase beta chain (EC 3.6.3.14), highly similar to
                     ATPB_MYCLE|P45823 Mycobacterium leprae (485 aa), FASTA
                     score: opt: 2916, E(): 0, (92.6% identity in 484 aa
                     overlap). Contains PS00017 ATP/GTP-binding site motif A,
                     PS00152 ATP synthase alpha and beta subunits signature.
                     SUBUNIT: F-TYPE ATPASES HAVE 2 COMPONENTS, CF(1) - THE
                     CATALYTIC CORE - AND CF(0) - THE MEMBRANE PROTON CHANNEL.
                     CF(1) HAS FIVE SUBUNITS: ALPHA(3), BETA(3), GAMMA(1),
                     DELTA(1), EPSILON(1). CF(0) HAS THREE MAIN SUBUNITS: A, B
                     AND C. BELONGS TO THE ATPASE ALPHA/BETA CHAINS FAMILY.
                     Protein product from Mb1342 detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb1342 found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:P63678"
                     /db_xref="InterPro:IPR000194"
                     /db_xref="InterPro:IPR003593"
                     /db_xref="InterPro:IPR004100"
                     /db_xref="InterPro:IPR005722"
                     /db_xref="InterPro:IPR020003"
                     /db_xref="InterPro:IPR024034"
                     /db_xref="InterPro:IPR027417"
                     /db_xref="InterPro:IPR036121"
                     /db_xref="UniProtKB/Swiss-Prot:P63678"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MTTTAEKTDR PGKPGSSDTS GRVVRVTGPV VDVEFPRGSI PELFNALHAE ITFESLAKTL
       61 TLEVAQHLGD NLVRTISLQP TDGLVRGVEV IDTGRSISVP VGEGVKGHVF NALGDCLDEP
      121 GYGEKFEHWS IHRKPPAFEE LEPRTEMLET GLKVVDLLTP YVRGGKIALF GGAGVGKTVL
      181 IQEMINRIAR NFGGTSVFAG VGERTREGND LWVELAEANV LKDTALVFGQ MDEPPGTRMR
      241 VALSALTMAE WFRDEQGQDV LLFIDNIFRF TQAGSEVSTL LGRMPSAVGY QPTLADEMGE
      301 LQERITSTRG RSITSMQAVY VPADDYTDPA PATTFAHLDA TTELSRAVFS KGIFPAVDPL
      361 ASSSTILDPS VVGDEHYRVA QEVIRILQRY KDLQDIIAIL GIDELSEEDK QLVNRARRIE
      421 RFLSQNMMAA EQFTGQPGST VPVKETIEAF DRLCKGDFDH VPEQAFFLIG GLDDLAKKAE
      481 SLGAKL
//