LOCUS       SIT99943.1               549 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            ATP SYNTHASE ALPHA CHAIN ATPA protein.
ACCESSION   LT708304-1355
PROTEIN_ID  SIT99943.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="atpA"
                     /locus_tag="BQ2027_MB1340"
                     /note="Mb1340, atpA, len: 549 aa. Equivalent to Rv1308,
                     len: 549 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100% identity in 549 aa overlap). Probable atpA, ATP
                     synthase alpha chain (EC 3.6.3.14), highly similar to
                     ATPA_MYCLE|P45825 from Mycobacterium leprae (558 aa),
                     FASTA scores: opt: 3233, E(): 0, (90.3% identity in 547 aa
                     overlap). Contains PS00017 ATP/GTP-binding site motif A,
                     PS00152 ATP synthase alpha and beta subunits signature.
                     SUBUNIT: F-TYPE ATPASES HAVE 2 COMPONENTS, CF(1) - THE
                     CATALYTIC CORE - AND CF(0) - THE MEMBRANE PROTON CHANNEL.
                     CF(1) HAS FIVE SUBUNITS: ALPHA(3), BETA(3), GAMMA(1),
                     DELTA(1), EPSILON(1). CF(0) HAS THREE MAIN SUBUNITS: A, B
                     AND C. BELONGS TO THE ATPASE ALPHA/BETA CHAINS FAMILY.
                     Protein product from Mb1340 detected using shotgun mass
                     spectrometry. Mb1340 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:P63674"
                     /db_xref="InterPro:IPR000194"
                     /db_xref="InterPro:IPR000793"
                     /db_xref="InterPro:IPR004100"
                     /db_xref="InterPro:IPR005294"
                     /db_xref="InterPro:IPR020003"
                     /db_xref="InterPro:IPR023366"
                     /db_xref="InterPro:IPR027417"
                     /db_xref="InterPro:IPR033732"
                     /db_xref="InterPro:IPR036121"
                     /db_xref="InterPro:IPR038376"
                     /db_xref="UniProtKB/Swiss-Prot:P63674"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MAELTIPADD IQSAIEEYVS SFTADTSREE VGTVVDAGDG IAHVEGLPSV MTQELLEFPG
       61 GILGVALNLD EHSVGAVILG DFENIEEGQQ VKRTGEVLSV PVGDGFLGRV VNPLGQPIDG
      121 RGDVDSDTRR ALELQAPSVV HRQGVKEPLQ TGIKAIDAMT PIGRGQRQLI IGDRKTGKTA
      181 VCVDTILNQR QNWESGDPKK QVRCVYVAIG QKGTTIAAVR RTLEEGGAMD YTTIVAAAAS
      241 ESAGFKWLAP YTGSAIAQHW MYEGKHVLII FDDLTKQAEA YRAISLLLRR PPGREAYPGD
      301 VFYLHSRLLE RCAKLSDDLG GGSLTGLPII ETKANDISAY IPTNVISITD GQCFLETDLF
      361 NQGVRPAINV GVSVSRVGGA AQIKAMKEVA GSLRLDLSQY RELEAFAAFA SDLDAASKAQ
      421 LERGARLVEL LKQPQSQPMP VEEQVVSIFL GTGGHLDSVP VEDVRRFETE LLDHMRASEE
      481 EILTEIRDSQ KLTEEAADKL TEVIKNFKKG FAATGGGSVV PDEHVEALDE DKLAKEAVKV
      541 KKPAPKKKK
//