LOCUS SIT99939.1 250 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE ATP SYNTHASE A CHAIN ATPB (PROTEIN 6) protein. ACCESSION LT708304-1351 PROTEIN_ID SIT99939.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="atpB" /locus_tag="BQ2027_MB1336" /note="Mb1336, atpB, len: 250 aa. Equivalent to Rv1304, len: 250 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 250 aa overlap). Probable atpB, ATP synthase A chain (EC 3.6.3.14), highly similar to ATP6_MYCLE|P45829 Mycobacterium leprae (251 aa), FASTA scores: opt: 1382, E(): 0, (84.0% identity in 250 aa overlap). Contains PS00449 ATP synthase A subunit signature. SUBUNIT: F-TYPE ATPASES HAVE 2 COMPONENTS, CF(1) - THE CATALYTIC CORE - AND CF(0) - THE MEMBRANE PROTON CHANNEL. CF(1) HAS FIVE SUBUNITS: ALPHA(3), BETA(3), GAMMA(1), DELTA(1), EPSILON(1). CF(0) HAS THREE MAIN SUBUNITS: A, B AND C. BELONGS TO THE ATPASE A CHAIN FAMILY. Protein product from Mb1336 detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb1336 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing (TPM > 20)." /db_xref="GOA:P63655" /db_xref="InterPro:IPR000568" /db_xref="InterPro:IPR023011" /db_xref="InterPro:IPR035908" /db_xref="UniProtKB/Swiss-Prot:P63655" /experiment="experimental evidence, no additional details recorded" BEGIN 1 MTETILAAQI EVGEHHTATW LGMTVNTDTV LSTAIAGLIV IALAFYLRAK VTSTDVPGGV 61 QLFFEAITIQ MRNQVESAIG MRIAPFVLPL AVTIFVFILI SNWLAVLPVQ YTDKHGHTTE 121 LLKSAAADIN YVLALALFVF VCYHTAGIWR RGIVGHPIKL LKGHVTLLAP INLVEEVAKP 181 ISLSLRLFGN IFAGGILVAL IALFPPYIMW APNAIWKAFD LFVGAIQAFI FALLTILYFS 241 QAMELEEEHH //