LOCUS       SIT99935.1               325 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            HEMK PROTEIN HOMOLOG HEMK protein.
ACCESSION   LT708304-1347
PROTEIN_ID  SIT99935.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="hemK"
                     /locus_tag="BQ2027_MB1332"
                     /note="Mb1332, hemK, len: 325 aa. Equivalent to Rv1300,
                     len: 325 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.7% identity in 325 aa overlap). Probable hemK protein
                     homolog (EC 2.1.1.-), homology suggests translation may
                     start at aa 22, highly similar to many e.g.
                     HEMK_MYCLE|P45832 Mycobacterium leprae (288 aa), FASTA
                     scores: opt: 936, E(): 0, (76.7% identity in 189 aa
                     overlap). BELONGS TO THE HEMK FAMILY OF MODIFICATION
                     METHYLASES. Mb1332 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3XYA7"
                     /db_xref="InterPro:IPR002052"
                     /db_xref="InterPro:IPR004556"
                     /db_xref="InterPro:IPR019874"
                     /db_xref="InterPro:IPR029063"
                     /db_xref="InterPro:IPR040758"
                     /db_xref="InterPro:IPR041698"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XYA7"
BEGIN
        1 MTSAPATMRW GNLPLAGESG TMTLRQAIDL AAALLAEAGV DSARCDAEQL AAHLAGTDRG
       61 RLPLFEPPGD EFFGRYRDIV TARARRVPLQ HLIGTVSFGP VVLHVGPGVF VPRPETEAIL
      121 AWATAQSLPA RPLIVDACTG SGALAVALAQ HRANLGLKAR IIGIDDSDCA LDYARRNAAG
      181 TPVELVRADV TTPCLLPELD GQVDLMVSNP PYIPDAAVLE PEVAQHDPHH ALFGGPDGMT
      241 VISAVVGLAG RWLRPGGLFA VEHDDTTSSS TVDLVSSTKL FVDVQARKDL AGRPRFVTAM
      301 RWGHLPLAGE NGAIDPRQRR CRAKR
//