LOCUS       SIT99922.1               405 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 Putative
            esterase protein.
ACCESSION   LT708304-1334
PROTEIN_ID  SIT99922.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB1319"
                     /note="Mb1319, -, len: 405 aa. Similar to Rv1288, len: 456
                     aa, from Mycobacterium tuberculosis strain H37Rv, (98.3%
                     identity in 403 aa overlap). Conserved hypothetical
                     protein, some similarity to A85B_MYCTU|P31952 antigen 85-b
                     precursor (85b) (325 aa), FASTA scores: opt: 199, E():
                     2.7e-06, (24.7% identity in 279 aa overlap). Also similar
                     to Q01377|CSP1_CORGL PS1 PROTEIN PRECURSOR (related to
                     antigen 85 complex) from Corynebacterium glutamicum (657
                     aa), FASTA scores: opt: 280, E(): 1.9e-10, (26.4% identity
                     in 352 aa overlap). SEEMS TO CONTAIN 3 LYSM REPEATS.
                     REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a
                     153 bp deletion leads to a shorter product compared to its
                     homolog in Mycobacterium tuberculosis strain H37Rv (405 aa
                     versus 456 aa). Protein product from Mb1319 detected using
                     SWATH mass spectrometry. Mb1319 found to be expressed
                     during exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="InterPro:IPR000801"
                     /db_xref="InterPro:IPR018392"
                     /db_xref="InterPro:IPR029058"
                     /db_xref="InterPro:IPR036779"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y024"
BEGIN
        1 MVSTHAVVAG ETLSALALRF YGDAELYRLI AAASGIADPD VVNVGQRLIM PDFTRYTVVA
       61 GDTLSALAAR FYGDASLYPL IAAVNGIADP GVIDVGQVLV IFIGRSDGFG LRIVDRNEND
      121 PRLWYYRFQT SAIGWNPGVN VLLPDDYRTS GRTYPVLYLF HGGGTDQDFR TFDFLGIRDL
      181 TAGKPIIIVM PDGGHAGWYS NPVSSFVGPR NWETFHIAQL LPWIEANFRT YAEYDGRAVA
      241 GFSMGGFGAL KYAAKYYGHF ASASSHSGPA SLRRDFGLVV HWANLSSAVL DLGGGTVYGA
      301 PLWDQARVSA DNPVERIDSY RNKRIFLVAG TSPDPANWFD SVNETQVLAG QREFRERLSN
      361 AGIPHESHEV PGGHVFRPDM FRLDLDGIVA RLRPASIGAA AERAD
//