LOCUS SIT99922.1 405 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 Putative esterase protein. ACCESSION LT708304-1334 PROTEIN_ID SIT99922.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB1319" /note="Mb1319, -, len: 405 aa. Similar to Rv1288, len: 456 aa, from Mycobacterium tuberculosis strain H37Rv, (98.3% identity in 403 aa overlap). Conserved hypothetical protein, some similarity to A85B_MYCTU|P31952 antigen 85-b precursor (85b) (325 aa), FASTA scores: opt: 199, E(): 2.7e-06, (24.7% identity in 279 aa overlap). Also similar to Q01377|CSP1_CORGL PS1 PROTEIN PRECURSOR (related to antigen 85 complex) from Corynebacterium glutamicum (657 aa), FASTA scores: opt: 280, E(): 1.9e-10, (26.4% identity in 352 aa overlap). SEEMS TO CONTAIN 3 LYSM REPEATS. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 153 bp deletion leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (405 aa versus 456 aa). Protein product from Mb1319 detected using SWATH mass spectrometry. Mb1319 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR036779" /db_xref="UniProtKB/TrEMBL:A0A1R3Y024" BEGIN 1 MVSTHAVVAG ETLSALALRF YGDAELYRLI AAASGIADPD VVNVGQRLIM PDFTRYTVVA 61 GDTLSALAAR FYGDASLYPL IAAVNGIADP GVIDVGQVLV IFIGRSDGFG LRIVDRNEND 121 PRLWYYRFQT SAIGWNPGVN VLLPDDYRTS GRTYPVLYLF HGGGTDQDFR TFDFLGIRDL 181 TAGKPIIIVM PDGGHAGWYS NPVSSFVGPR NWETFHIAQL LPWIEANFRT YAEYDGRAVA 241 GFSMGGFGAL KYAAKYYGHF ASASSHSGPA SLRRDFGLVV HWANLSSAVL DLGGGTVYGA 301 PLWDQARVSA DNPVERIDSY RNKRIFLVAG TSPDPANWFD SVNETQVLAG QREFRERLSN 361 AGIPHESHEV PGGHVFRPDM FRLDLDGIVA RLRPASIGAA AERAD //