LOCUS       SIT99892.1                97 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            OXIDOREDUCTASE [SECOND PART] protein.
ACCESSION   LT708304-1304
PROTEIN_ID  SIT99892.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB1291"
                     /note="Mb1291, -, len: 102 aa. Equivalent to 3' end of
                     Rv1260, len: 372 aa, from Mycobacterium tuberculosis
                     strain H37Rv, (100% identity in 102 aa overlap). Probable
                     oxidoreductase (EC 1.-.-.-), highly similar to
                     E1245747|AL021411 putative oxidoreductase SC7H1.18 from
                     Streptomyces coelicolor (397 aa), FASTA scores: E():
                     1.4e-29, (45.9% identity in 355 aa overlap); also some
                     similarity to G912582 FAD binding protein homologue from
                     Pseudomonas aeruginosa (286 aa), FASTA scores: opt: 245,
                     E(): 2e-09, (27.5% identity in 251 aa overlap);
                     PCPB_FLASP|P42535 pentachlorophenol 4-monooxygenase (537
                     aa), FASTA scores: opt: 219, E(): 1.7e-07, (23.3% identity
                     in 360 aa overlap); TETX_BACFR|Q01911 tetracycline
                     resistance protein (388 aa), FASTA scores: opt: 183, E():
                     3e-05, (22.8% identity in 373 aa overlap). Also similar to
                     Mycobacterium tuberculosis hypothetical proteins Rv0575c
                     and Rv1751. REMARK-M.bovis-M.tuberculosis: In
                     Mycobacterium tuberculosis strain H37Rv, Rv1260 exists as
                     a single gene. In Mycobacterium bovis, a frameshift due to
                     a single base deletion (g-*) splits Rv1260 into 2 parts,
                     Mb1290 and Mb1291. Protein product from Mb1291 detected
                     using SWATH mass spectrometry. Mb1291 found to be
                     expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
                     /db_xref="GOA:A0A1R3XZY9"
                     /db_xref="InterPro:IPR002938"
                     /db_xref="InterPro:IPR036188"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XZY9"
BEGIN
        1 MDRWSRGRVA LVGDAGYCCS PLSGQGTSVA LLGAYILAGE LKAAGDDYQL GFANYHAEFH
       61 GFVERNQWLV SDNIPGGAPI PQEEFERIVH SITIKDY
//