LOCUS       SIT99886.1               563 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            COLD-SHOCK DEAD-BOX PROTEIN A HOMOLOG DEAD (ATP-dependent
            RNA helicase deaD homolog) protein.
ACCESSION   LT708304-1298
PROTEIN_ID  SIT99886.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="deaD"
                     /locus_tag="BQ2027_MB1285"
                     /note="Mb1285, deaD, len: 563 aa. Equivalent to Rv1253,
                     len: 563 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.8% identity in 563 aa overlap). Probable Dead,
                     Cold-shock DEAD-box protein A homolog, similar to many
                     e.g. DEAD_ECOLI|P23304 Escherichia coli (646 aa), FASTA
                     scores: opt: 1490, E(): 0, (46.7% identity in 578 aa
                     overlap); similar to Mycobacterium tuberculosis Rv3211.
                     Contains PS00017 ATP/GTP-binding site motif A, PS00039
                     DEAD-box subfamily ATP-dependent helicases signature.
                     BELONGS TO THE DEAD BOX FAMILY HELICASE. Protein product
                     from Mb1285 detected using shotgun mass spectrometry and
                     SWATH mass spectrometry. Mb1285 found to be expressed
                     during exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3XXT6"
                     /db_xref="InterPro:IPR000629"
                     /db_xref="InterPro:IPR001650"
                     /db_xref="InterPro:IPR005580"
                     /db_xref="InterPro:IPR011545"
                     /db_xref="InterPro:IPR012677"
                     /db_xref="InterPro:IPR014001"
                     /db_xref="InterPro:IPR014014"
                     /db_xref="InterPro:IPR027417"
                     /db_xref="InterPro:IPR028618"
                     /db_xref="InterPro:IPR034415"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XXT6"
BEGIN
        1 MAFPEYSPAA SAATFADLQI HPRVLRAIGD VGYESPTAIQ AATIPALMAG SDVVGLAQTG
       61 TGKTAAFAIP MLSKIDITSK VPQALVLVPT RELALQVAEA FGRYGAYLSQ LNVLPIYGGS
      121 SYAVQLAGLR RGAQVVVGTP GRVIDHLERA TLDLSRVDFL VLDEADEMLT MGFADDVERI
      181 LSETPEYKQV ALFSATMPPA IRKLSAKYLH DPFEVTCKAK TAVAENISQS YIQVARKMDA
      241 LTRVLEVEPF EAMIVFVRTK QATEEIAEKL RARGFSAAAI SGDVPQAQRE RTITALRDGD
      301 IDILVATDVA ARGLDVERIS HVLNYDIPHD TESYVHRIGR TGRAGRSGAA LIFVSPRELH
      361 LLKAIEKATR QTLTEAQLPT VEDVNTQRVA KFADSITNAL GGPGIELFRR LVEEYEREHD
      421 VPMADIAAAL AVQCRGGEAF LMAPDPPLSR RNRDQRRDRP QRPKRRPDLT TYRVAVGKRH
      481 KIGPGAIVGA IANEGGLHRS DFGQIRIGPD FSLVELPAKL PRATLKKLAQ TRISGVLIDL
      541 RPYRPPDAAR RHNGGKPRRK HVG
//