LOCUS       SIT99878.1               276 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE protein.
ACCESSION   LT708304-1290
PROTEIN_ID  SIT99878.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB1277C"
                     /note="Mb1277c, -, len: 276 aa. Equivalent to Rv1245c,
                     len: 276 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100% identity in 276 aa overlap). Probable short-chain
                     dehydrogenase/reductase (EC 1.-.-.-), equivalent to
                     NP_301801.1|NC_002677 short chain alcohol dehydrogenase
                     from Mycobacterium leprae (277 aa). Also highly similar to
                     various dehydrogenases and oxidoreductases e.g.
                     NP_250228.1|NC_002516 probable short-chain dehydrogenase
                     from Pseudomonas aeruginosa (295 aa);
                     NP_421969.1|NC_002696 short chain dehydrogenase family
                     protein from Caulobacter crescentus (278 aa); etc. Also
                     highly similar to others from Mycobacterium tuberculosis
                     e.g. Rv3085|MTV013.06 PROBABLE SHORT-CHAIN TYPE
                     DEHYDROGENASE/REDUCTASE (276 aa), FASTA scores: opt: 368,
                     E(): 1.2e-16, (35.3% identity in 224 aa overlap);
                     Rv3057c|MTCY22D7.24 PUTATIVE SHORT CHAIN ALCOHOL
                     DEHYDROGENASE/REDUCTASE (287 aa), FASTA scores: opt: 471,
                     E(): 1.3e-21, (32.4% identity in 281 aa overlap); etc.
                     Contains PS00061 Short-chain dehydrogenases/reductases
                     family signature. BELONGS TO THE SHORT-CHAIN
                     DEHYDROGENASES/REDUCTASES (SDR) FAMILY. Protein product
                     from Mb1277c detected using shotgun mass spectrometry and
                     SWATH mass spectrometry. Mb1277c found to be expressed
                     during exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3XXS4"
                     /db_xref="InterPro:IPR002347"
                     /db_xref="InterPro:IPR020904"
                     /db_xref="InterPro:IPR036291"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XXS4"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MEGFAGKVAV VTGAGSGIGQ ALAIELARSG AKVAISDVDT DGLADTEHRL KAISTPVKTD
       61 RLDVTEREAF LAYADAVNEH FGTVNQIYNN AGIAFTGDIE VSQFKDIERV MDVDFWGVVN
      121 GTKAFLPHLI ASGDGHVINI SSVFGLFSAP GQAAYNSAKF AVRGFTEALR QEMALAGHPV
      181 KVTTVHPGGV KTAIARNATA AEGLDQAELA ETFDKRVAHL SPQRAAQIIL TGVAKNKARV
      241 LVGVDAKVLD LVVRLTGSGY QRIFPIITGR LIPRPR
//