LOCUS       SIT99872.1               366 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE
            MAGNESIUM AND COBALT TRANSPORT TRANSMEMBRANE PROTEIN CORA
            protein.
ACCESSION   LT708304-1284
PROTEIN_ID  SIT99872.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="corA"
                     /locus_tag="BQ2027_MB1271C"
                     /note="Mb1271c, corA, len: 366 aa. Equivalent to Rv1239c,
                     len: 366 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.5% identity in 366 aa overlap). Possible corA,
                     magnesium and cobalt transport transmembrane protein,
                     highly similar to U15180 corA protein from Mycobacterium
                     leprae (373 aa), FASTA scores: opt: 1985, E(): 0, (79.1%
                     identity in 369 aa overlap). Also similar to various CorA
                     proteins of Gram negative bacteria e.g.
                     P27841|CORA_ECOLI|B3816|Z5333|ECS4746 Magnesium and cobalt
                     transport protein from Escherichia coli strains K12 and
                     O157:H7 (316 aa), FASTA scores: opt: 236, E(): 8e-08,
                     (24.5% identity in 306 aa overlap); etc. SEEMS TO BELONG
                     TO THE MIT FAMILY. Protein product from Mb1271c detected
                     using shotgun mass spectrometry and SWATH mass
                     spectrometry. Mb1271c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3XZW9"
                     /db_xref="InterPro:IPR002523"
                     /db_xref="InterPro:IPR004488"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XZW9"
BEGIN
        1 MFPGFDALPE VLRPVARPQP PNAHPVAQPP AQALVDCGVY VCGQRLPGKY TYAAALREVR
       61 EIELTGQEAF VWIGLHEPDE NQMQDVADVF GLHPLAVEDA VHAHQRPKLE RYDETLFLVL
      121 KTVNYVPHES VVLAREIVET GEIMIFVGKD FVVTVRHGEH GGLSEVRKRM DADPEHLRLG
      181 PYAVMHAIAD YVVDRYLEVT NLMETDIDSI EEVAFAPGRK LDIEPIYLLK REVVELRRCV
      241 NPLSTAFQRM QTESKDLISK EVRRYLRDVA DHQTEAADQI ASYDDMLNSL VQAALARVGM
      301 QQNMDMRKIS AWAGIIAVPT MIAGIYGMNF HFMPELDSRW GYPTVIGGMV LICLFLYHVF
      361 RNRNWL
//