LOCUS       SIT99856.1               528 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            SERINE PROTEASE HTRA (DEGP PROTEIN) protein.
ACCESSION   LT708304-1268
PROTEIN_ID  SIT99856.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="htrA"
                     /locus_tag="BQ2027_MB1255"
                     /note="Mb1255, htrA, len: 528 aa. Equivalent to Rv1223,
                     len: 528 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.6% identity in 528 aa overlap). Probable htrA
                     (alternate gene name: degP), serine protease precursor (EC
                     3.4.21.-), equivalent to
                     U15180|MLU15180_31|Q49972|ML1078|HTRA POSSIBLE SERINE
                     PROTEASE from Mycobacterium leprae (533 aa), FASTA scores:
                     opt: 2777, E(): 4.1e-141, (81.6% identity in 533 aa
                     overlap). Also similar to many others e.g.
                     HTRA_ECOLI|P09376 protease do precursor from Escherichia
                     coli (EC 3.4.21.-) (474 aa), FASTA scores: opt: 581, E():
                     9.1e-27, (36.3% identity in 278 aa overlap); etc. Contains
                     PS00017 ATP/GTP-binding site motif A (P-loop). Start
                     changed since first submission (-21 aa). Protein product
                     from Mb1255 detected using shotgun mass spectrometry and
                     SWATH mass spectrometry. Mb1255 found to be expressed
                     during exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3XXQ7"
                     /db_xref="InterPro:IPR001478"
                     /db_xref="InterPro:IPR001940"
                     /db_xref="InterPro:IPR009003"
                     /db_xref="InterPro:IPR036034"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XXQ7"
BEGIN
        1 MDTRVDTDNA MPARFSAQIQ NEDEVTSDQG NNGGPNGGGR LAPRPVFRPP VDPASRQAFG
       61 RPSGVQGSFV AERVRPQKYQ DQSDFTPNDQ LADPVLQEAF GRPFAGAESL QRHPIDAGAL
      121 AAEKDGAGPD EPDDPWRDPA AAAALGTPAL AAPAPHGALA GSGKLGVRDV LFGGKVSYLA
      181 LGILVAIALV IGGIGGVIGR KTAEVVDAFT TSKVTLSTTG NAQEPAGRFT KVAAAVADSV
      241 VTIESVSDQE GMQGSGVIVD GRGYIVTNNH VISEAANNPS QFKTTVVLND GKEVPANLVG
      301 RDPKTDLAVL KVDNVDNLTV ARLGDSSKVR VGDEVLAVGA PLGLRSTVTQ GIVSALHRPV
      361 PLSGEGSDTD TVIDAIQTDA SINHGNSGGP LIDMDAQVIG INTAGKSLSD SASGLGFAIP
      421 VNEMKLVANS LIKDGKIVHP TLGINTRSVS NAIASGAQVA NVKAGSPAQK GGILENDVIV
      481 KVGNRAVADS DEFVVAVRQL AIGQDAPIEV VREGRHVTLT VKPDPDST
//