LOCUS SIT99852.1 212 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN protein. ACCESSION LT708304-1264 PROTEIN_ID SIT99852.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB1251C" /note="Mb1251c, -, len: 212 aa. Equivalent to Rv1219c, len: 212 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 212 aa overlap). Probable transcriptional regulatory protein, some similarity in N-terminus to YBIH_ECOLI|P41037 hypothetical transcriptional regulator from Escherichia coli (103 aa), FASTA scores: opt: 143, E(): 8.9e-06, (39.7% identity in 63 aa overlap); Helix turn helix motif from aa 28-49. Protein product from Mb1251c detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb1251c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing (TPM > 20)." /db_xref="GOA:A0A1R3XZU0" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="InterPro:IPR041484" /db_xref="UniProtKB/TrEMBL:A0A1R3XZU0" BEGIN 1 MRSADLTAHA RIREAAIEQF GRHGFGVGLR AIAEAAGVSA ALVIHHFGSK EGLRKACDDF 61 VAEEIRSSKA AALKSNDPTT WLAQMAEIES YAPLMAYLVR SMQSGGELAK MLWQKMIDNA 121 EEYLDEGVRA GTVKPSRDPR ARARFLAITG GGGFLLYLQM HENPTDLRAA LRDYAHDMVL 181 PSLEVYTEGL LADRAMYEAF LAEAQQGEAH VG //