LOCUS SIT99851.1 311 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE TETRONASIN-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER protein. ACCESSION LT708304-1263 PROTEIN_ID SIT99851.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB1250C" /note="Mb1250c, -, len: 311 aa. Equivalent to Rv1218c, len: 311 aa, from Mycobacterium tuberculosis strain H37Rv, (99.7% identity in 311 aa overlap). Probable tetronasin-transport ATP-binding protein ABC transporter (see citation below), similar to many e.g. Q54406|X73633|TNRB2 TNRB2 PROTEIN from Streptomyces longisporoflavus (300 aa), FASTA scores: opt: 1133, E(): 0, (60.8% identity in 291 aa overlap); etc. Also similar to others in Mycobacterium tuberculosis e.g. MTCY19H9.04 (30.0% identity in 297 aa overlap); etc. Contains PS00211 ABC transporters family signature and PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS) Protein product from Mb1250c detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb1250c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:A0A1R3XXQ1" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR025302" /db_xref="InterPro:IPR027417" /db_xref="UniProtKB/TrEMBL:A0A1R3XXQ1" BEGIN 1 MSADNHQVPI EIRGLTKHFG SVRALDGLDL TVREGEVHGF LGPNGAGKST TLRILLGLVK 61 ADGGSVRLLG GDPWTDAVDL HRHIAYVPGD VTLWPSLTGG ETIDLLARMR GGIDNARRAE 121 LIERFGLDPT KKARTYSKGN RQKVSLISAL SSHATLLLLD EPSSGLDPLM ENVFQQCIGE 181 ARQRGVTVLL SSHILAETEA LCEKVTIIRA GKTVESGSLD ALRHLSRTSI KAEMIGDPGD 241 LSRIKGVEDI SIEGTTVRAQ VDSESLRELI QVLGHAGVRS LVSQPPTLEE LFLRHYSLGP 301 EVAAEQQVAT P //