LOCUS       SIT99846.1               404 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 glucose-
            1-phosphate adenylyltransferase glgc (adp-glucose synthase)
            (adp-glucose pyrophosphorylase) protein.
ACCESSION   LT708304-1258
PROTEIN_ID  SIT99846.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="glgC"
                     /locus_tag="BQ2027_MB1245"
                     /note="Mb1245, glgC, len: 404 aa. Equivalent to Rv1213,
                     len: 404 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100% identity in 404 aa overlap). Probable glgC,
                     glucose-1-phosphate adenylyltransferase (EC 2.7.7.27),
                     similar to many e.g. GLGC_ECOLI|P00584 Escherichia coli
                     (430 aa), FASTA scores: opt: 1075, E(): 0, (40.3% identity
                     in 407 aa overlap); highly similar to Q49961 GLGC from
                     Mycobacterium leprae (419 aa), FASTA scores: opt: 2532,
                     E(): 0, (92.6% identity in 404 aa overlap). BELONGS TO THE
                     BACTERIAL AND PLANTS GLUCOSE-1-PHOSPHATE
                     ADENYLYLTRANSFERASE FAMILY. Protein product from Mb1245
                     detected using shotgun mass spectrometry and SWATH mass
                     spectrometry. Mb1245 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:P64242"
                     /db_xref="InterPro:IPR005835"
                     /db_xref="InterPro:IPR005836"
                     /db_xref="InterPro:IPR011004"
                     /db_xref="InterPro:IPR011831"
                     /db_xref="InterPro:IPR023049"
                     /db_xref="InterPro:IPR029044"
                     /db_xref="UniProtKB/Swiss-Prot:P64242"
BEGIN
        1 MREVPHVLGI VLAGGEGKRL YPLTADRAKP AVPFGGAYRL IDFVLSNLVN ARYLRICVLT
       61 QYKSHSLDRH ISQNWRLSGL AGEYITPVPA QQRLGPRWYT GSADAIYQSL NLIYDEDPDY
      121 IVVFGADHVY RMDPEQMVRF HIDSGAGATV AGIRVPRENA TAFGCIDADD SGRIRSFVEK
      181 PLEPPGTPDD PDTTFVSMGN YIFTTKVLID AIRADADDDH SDHDMGGDIV PRLVADGMAA
      241 VYDFSDNEVP GATDRDRAYW RDVGTLDAFY DAHMDLVSVH PVFNLYNKRW PIRGESENLA
      301 PAKFVNGGSA QESVVGAGSI ISAASVRNSV LSSNVVVDDG AIVEGSVIMP GTRVGRGAVV
      361 RHAILDKNVV VGPGEMVGVD LEKDRERFAI SAGGVVAVGK GVWI
//