LOCUS SIT99846.1 404 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 glucose- 1-phosphate adenylyltransferase glgc (adp-glucose synthase) (adp-glucose pyrophosphorylase) protein. ACCESSION LT708304-1258 PROTEIN_ID SIT99846.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="glgC" /locus_tag="BQ2027_MB1245" /note="Mb1245, glgC, len: 404 aa. Equivalent to Rv1213, len: 404 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 404 aa overlap). Probable glgC, glucose-1-phosphate adenylyltransferase (EC 2.7.7.27), similar to many e.g. GLGC_ECOLI|P00584 Escherichia coli (430 aa), FASTA scores: opt: 1075, E(): 0, (40.3% identity in 407 aa overlap); highly similar to Q49961 GLGC from Mycobacterium leprae (419 aa), FASTA scores: opt: 2532, E(): 0, (92.6% identity in 404 aa overlap). BELONGS TO THE BACTERIAL AND PLANTS GLUCOSE-1-PHOSPHATE ADENYLYLTRANSFERASE FAMILY. Protein product from Mb1245 detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb1245 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:P64242" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005836" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR011831" /db_xref="InterPro:IPR023049" /db_xref="InterPro:IPR029044" /db_xref="UniProtKB/Swiss-Prot:P64242" BEGIN 1 MREVPHVLGI VLAGGEGKRL YPLTADRAKP AVPFGGAYRL IDFVLSNLVN ARYLRICVLT 61 QYKSHSLDRH ISQNWRLSGL AGEYITPVPA QQRLGPRWYT GSADAIYQSL NLIYDEDPDY 121 IVVFGADHVY RMDPEQMVRF HIDSGAGATV AGIRVPRENA TAFGCIDADD SGRIRSFVEK 181 PLEPPGTPDD PDTTFVSMGN YIFTTKVLID AIRADADDDH SDHDMGGDIV PRLVADGMAA 241 VYDFSDNEVP GATDRDRAYW RDVGTLDAFY DAHMDLVSVH PVFNLYNKRW PIRGESENLA 301 PAKFVNGGSA QESVVGAGSI ISAASVRNSV LSSNVVVDDG AIVEGSVIMP GTRVGRGAVV 361 RHAILDKNVV VGPGEMVGVD LEKDRERFAI SAGGVVAVGK GVWI //