LOCUS       SIT99822.1               290 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE
            ALTERNATIVE RNA POLYMERASE SIGMA FACTOR SIGI protein.
ACCESSION   LT708304-1234
PROTEIN_ID  SIT99822.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="sigI"
                     /locus_tag="BQ2027_MB1221"
                     /note="Mb1221, sigI, len: 290 aa. Equivalent to Rv1189,
                     len: 290 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100% identity in 290 aa overlap). Possible sigI,
                     alternative RNA polymerase sigma factor (see citation
                     below), similar to several e.g. O05767|U87307
                     extracytoplasmic function alternative sigma factor (sigE)
                     from M. smegmatis (204 aa), FASTA scores: opt: 239, E():
                     1.3e-09, (32.9% identity in 167 aa overlap). Mb1221 found
                     to be expressed during exponential growth in Sauton's
                     minimal media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:A0A1R3XZQ9"
                     /db_xref="InterPro:IPR007627"
                     /db_xref="InterPro:IPR013249"
                     /db_xref="InterPro:IPR013324"
                     /db_xref="InterPro:IPR013325"
                     /db_xref="InterPro:IPR014284"
                     /db_xref="InterPro:IPR032710"
                     /db_xref="InterPro:IPR036388"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XZQ9"
BEGIN
        1 MSQHDPVSAA WRAHRAYLVD LAFRMVGDIG VAEDMVQEAF SRLLRAPVGD IDDERGWLIV
       61 VTSRLCLDHI KSASTRRERP QDIAAWHDGD ASVSSVDPAD RVTLDDEVRL ALLIMLERLG
      121 PAERVVFVLH EIFGLPYQQI ATTIGSQAST CRQLAHRARR KINESRIAAS VEPAQHRVVT
      181 RAFIEACSNG DLDTLLEVLD PGVAGEIDAR KGVVVVGADR VGPTILRHWS HPATVLVAQP
      241 VCGQPAVLAF VNRALAGVLA LSIEAGKITK IHVLVQPSTL DPLRAELGGG
//