LOCUS       SIT99821.1               329 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            PROLINE DEHYDROGENASE protein.
ACCESSION   LT708304-1233
PROTEIN_ID  SIT99821.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB1220"
                     /note="Mb1220, -, len: 329 aa. Equivalent to Rv1188, len:
                     329 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100% identity in 329 aa overlap). Possible putA, proline
                     dehydrogenase (EC 1.5.99.8), similar to part of
                     Q52711|X78346 proline dehydrogenase from Rhodobacter
                     capsulatus (1127 aa), FASTA scores: opt: 194, E():
                     1.5e-07, (31.2% identity in 349 aa overlap). Also similar
                     to two Bacillus subtilis proline dehydrohenases
                     E1184363|Z99120 (302 aa), FASTA scores: opt: 509, E(): 0,
                     (37.1% identity in 313 aa overlap); and E1182272|Z99105
                     (303 aa), FASTA scores: opt: 513, E(): 0, (32.5% identity
                     in 311 aa overlap). Highly similar to AL035569|SC8D9.31
                     Streptomyces coelicolor (308 aa), FASTA scores: opt: 984,
                     E(): 0, (50.0% identity in 312 aa overlap). Protein
                     product from Mb1220 detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb1220 found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
                     /db_xref="GOA:A0A1R3XXM0"
                     /db_xref="InterPro:IPR002872"
                     /db_xref="InterPro:IPR008219"
                     /db_xref="InterPro:IPR015659"
                     /db_xref="InterPro:IPR029041"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XXM0"
BEGIN
        1 MAGWFAHTLR PAMLAAGRSD RLGRIVERSP LTRGVVRRFV PGDTLDDVVD IVTALRDSGR
       61 YLSIDYLGEN VTDADDAAAA VRAYLGLLDV LGRRGDIACD GVRPLEVSLK LSALGQALDR
      121 DGQKIALDNA RAICERAERV GAWVTVDAED HTTTDSTLSI SGDLRVDFPW LGTVVQAYLR
      181 RTLADCAELA AVGARVRLCK GAYDEPASVA YRDAAQVTDS YLRCLRVLTA GRGYPMVATH
      241 DPVIIAAVPG ITRESGRSQG DFEYQMLYGV RDDEQRRLTG AGNHVRVYVP FGTRWYGYFL
      301 RRLAERPANL AFFLRALTDR RRARGCAER
//