LOCUS       SIT99818.1               578 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 probable
            fatty-acid-amp ligase fadd21 (fatty-acid-amp synthetase)
            (fatty-acid-amp synthase) protein.
ACCESSION   LT708304-1230
PROTEIN_ID  SIT99818.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="fadD21"
                     /locus_tag="BQ2027_MB1217C"
                     /note="Mb1217c, fadD21, len: 578 aa. Equivalent to
                     Rv1185c, len: 578 aa, from Mycobacterium tuberculosis
                     strain H37Rv, (100% identity in 578 aa overlap). Probable
                     fadD21, fatty-acid-CoA synthetase (EC 6.2.1.-), highly
                     similar to several from Mycobacteria e.g.
                     NP_301895.1|NC_002677 possible acyl-CoA synthase from
                     Mycobacterium leprae (579 aa); P71495|U75685 ACYL-COA
                     SYNTHASE from Mycobacterium bovis (582 aa), FASTA scores:
                     opt: 2388, E(): 0, (61.8% identity in 579 aa overlap);
                     etc. SEEMS TO BELONG TO THE ATP-DEPENDENT AMP-BINDING
                     ENZYME FAMILY. Protein product from Mb1217c detected using
                     shotgun mass spectrometry and SWATH mass spectrometry.
                     Mb1217c found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing."
                     /db_xref="GOA:P63524"
                     /db_xref="InterPro:IPR000873"
                     /db_xref="InterPro:IPR040097"
                     /db_xref="InterPro:IPR042099"
                     /db_xref="UniProtKB/Swiss-Prot:P63524"
BEGIN
        1 MSDSSVLSLL RERAGLQPDD AAFTYIDYEQ DWAGITETLT WSEVFRRTRI VAHEVRRHCT
       61 TGDRAVILAP QGLAYIAAFL GSMQAGAIAV PLSVPQIGSH DERVSAVLAD ASPSVILTTS
      121 AVAEAVAEHI HRPNTNNVGP IIEIDSLDLT GNSPSFRVKD LPSAAYLQYT SGSTRAPAGV
      181 MISHRNLQAN FQQLMSNYFG DRNGVAPPDT TIVSWLPFYH DMGLVLGIIA PILGGYRSEL
      241 TSPLAFLQRP ARWLHSLANG SPSWSAAPNF AFELAVRKTT DADIEGLDLG NVLGITSGAE
      301 RVHPNTLSRF CNRFAPYNFR EDMIRPSYGL AEATLYVASR NSGDKPEVVY FEPDKLSTGS
      361 ANRCEPKTGT PLLSYGMPTS PTVRIVDPDT CIECPAGTIG EIWVKGDNVA EGYWNKPDET
      421 RHTFGAMLVH PSAGTPDGSW LRTGDLGFLS EDEMFIVGRM KDMLIVYGRN HYPEDIESTV
      481 QEITGGRVAA ISVPVDHTEK LVTVIELKLL GDSAGEAMDE LDVIKNNVTA AISRSHGLNV
      541 ADLVLVPPGS IPTTTSGKIR RAACVEQYRL QQFTRLDG
//