LOCUS       SIT99815.1               472 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            CONSERVED POLYKETIDE SYNTHASE ASSOCIATED PROTEIN PAPA3
            protein.
ACCESSION   LT708304-1227
PROTEIN_ID  SIT99815.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="papA3"
                     /locus_tag="BQ2027_MB1214"
                     /note="Mb1214, papA3, len: 472 aa. Equivalent to Rv1182,
                     len: 472 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100% identity in 472 aa overlap). Probable papA3,
                     conserved polyketide synthase (PKS) associated protein,
                     similar to other Mycobacterial hypothetical proteins e.g.
                     Q49618|U00010 B1170_C1_180 from Mycobacterium leprae (471
                     aa), FASTA scores: opt: 2526, E(): 0, (75.6% identity in
                     471 aa overlap). Similar to other Mycobacterium
                     tuberculosis hypothetical papA proteins; Rv3824c, Rv3820c,
                     Rv1528c. Protein product from Mb1214 detected using SWATH
                     mass spectrometry. Mb1214 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="InterPro:IPR001242"
                     /db_xref="InterPro:IPR023213"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XXY4"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MLRVGPLTIG TLDDWAPSTG STVSWRPSAV AHTKASQAPI SDVPVSYMQA QHIRGYCEQK
       61 AKGLDYSRLM VVSCQQPGQC DIRAANYVIN AHLRRHDTYR SWFQYNGNGQ IIRRTIQDPA
      121 DIEFVPVHHG ELTLPQIREI VQNTPDPLQW GCFRFGIVQG CDHFTFFASV DHVHVDAMIV
      181 GVTLMEFHLM YAALVGGHAP LELPPAGSYD DFCRRQHTFS STLTVESPQV RAWTKFAEGT
      241 NGSFPDFPLP LGDPSKPSDA DIVTVMMLDE EQTAQFESVC TAAGARFIGG VLACCGLAEH
      301 ELTGTTTYYG LTPRDTRRTP ADAMTQGWFT GLIPITVPIA GSAFGDAARA AQTSFDSGVK
      361 LAEVPYDRVV ELSSTLTMPR PNFPVVNFLD AGAAPLSVLL TAELTGTNIG VYSDGRYSYQ
      421 LSIYVIRVEQ GTAVAVMFPD NPIARESVAR YLATLKSVFQ RVAESGQQQN VA
//