LOCUS SIT99807.1 856 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE F420 BIOSYNTHESIS PROTEIN FBIC protein. ACCESSION LT708304-1219 PROTEIN_ID SIT99807.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="fbiC" /locus_tag="BQ2027_MB1206" /note="Mb1206, fbiC, len: 856 aa. Equivalent to Rv1173, len: 856 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 856 aa overlap). Probable fbiC, F420 biosynthesis protein, equivalent to AAL91922|FBIC F420 biosynthesis protein fbiC from Mycobacterium bovis BCG (856 aa) (see citation below). The N-terminus (aa 80-420) is similar to Y446_METJA|Q57888 hypothetical protein mj0446 from methanococcus jannaschii (361 aa), FASTA scores: opt: 801, E(): 0, (41.2% identity in 337 aa overlap); and the C-terminus region (aa 530-856) is similar to e.g. YE31_METJA|Q58826 hypothetical protein mj1431 from methanococcus jannaschii (359 aa), FASTA scores: opt: 1089, E(): 0, (48.7% identity in 337 aa overlap). Protein product from Mb1206 detected using SWATH mass spectrometry. Mb1206 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:Q7U0G9" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR019939" /db_xref="InterPro:IPR019940" /db_xref="InterPro:IPR020050" /db_xref="InterPro:IPR034405" /db_xref="UniProtKB/Swiss-Prot:Q7U0G9" BEGIN 1 MPQPVGRKST ALPSPVVPPQ ANASALRRVL RRARDGVTLN VDEAAIAMTA RGDELADLCA 61 SAARVRDAGL VSAGRHGPSG RLAISYSRKV FIPVTRLCRD NCHYCTFVTV PGKLRAQGSS 121 TYMEPDEILD VARRGAEFGC KEALFTLGDR PEARWRQARE WLGERGYDST LSYVRAMAIR 181 VLEQTGLLPH LNPGVMSWSE MSRLKPVAPS MGMMLETTSR RLFETKGLAH YGSPDKDPAV 241 RLRVLTDAGR LSIPFTTGLL VGIGETLSER ADTLHAIRKS HKEFGHIQEV IVQNFRAKEH 301 TAMAAFPDAG IEDYLATVAV ARLVLGPGMR IQAPPNLVSG DECRALVGAG VDDWGGVSPL 361 TPDHVNPERP WPALDELAAV TAEAGYDMVQ RLTAQPKYVQ AGAAWIDPRV RGHVVALADP 421 ATGLARDVNP VGMPWQEPDD VASWGRVDLG AAIDTQGRNT AVRSDLASAF GDWESIREQV 481 HELAVRAPER IDTDVLAALR SAERAPAGCT DGEYLALATA DGPALEAVAA LADSLRRDVV 541 GDEVTFVVNR NINFTNICYT GCRFCAFAQR KGDADAYSLS VGEVADRAWE AHVAGATEVC 601 MQGGIDPELP VTGYADLVRA VKARVPSMHV HAFSPMEIAN GVTKSGLSIR EWLIGLREAG 661 LDTIPGTAAE ILDDEVRWVL TKGKLPTSLW IEIVTTAHEV GLRSSSTMMY GHVDSPRHWV 721 AHLNVLRDIQ DRTGGFTEFV PLPFVHQNSP LYLAGAARPG PSHRDNRAVH ALARIMLHGR 781 ISHIQTSWVK LGVRRTQVML EGGANDLGGT LMEETISRMA GSEHGSAKTV AELVAIAEGI 841 GRPARQRTTT YALLAA //