LOCUS       SIT99807.1               856 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            F420 BIOSYNTHESIS PROTEIN FBIC protein.
ACCESSION   LT708304-1219
PROTEIN_ID  SIT99807.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="fbiC"
                     /locus_tag="BQ2027_MB1206"
                     /note="Mb1206, fbiC, len: 856 aa. Equivalent to Rv1173,
                     len: 856 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100% identity in 856 aa overlap). Probable fbiC, F420
                     biosynthesis protein, equivalent to AAL91922|FBIC F420
                     biosynthesis protein fbiC from Mycobacterium bovis BCG
                     (856 aa) (see citation below). The N-terminus (aa 80-420)
                     is similar to Y446_METJA|Q57888 hypothetical protein
                     mj0446 from methanococcus jannaschii (361 aa), FASTA
                     scores: opt: 801, E(): 0, (41.2% identity in 337 aa
                     overlap); and the C-terminus region (aa 530-856) is
                     similar to e.g. YE31_METJA|Q58826 hypothetical protein
                     mj1431 from methanococcus jannaschii (359 aa), FASTA
                     scores: opt: 1089, E(): 0, (48.7% identity in 337 aa
                     overlap). Protein product from Mb1206 detected using SWATH
                     mass spectrometry. Mb1206 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:Q7U0G9"
                     /db_xref="InterPro:IPR006638"
                     /db_xref="InterPro:IPR007197"
                     /db_xref="InterPro:IPR013785"
                     /db_xref="InterPro:IPR019939"
                     /db_xref="InterPro:IPR019940"
                     /db_xref="InterPro:IPR020050"
                     /db_xref="InterPro:IPR034405"
                     /db_xref="UniProtKB/Swiss-Prot:Q7U0G9"
BEGIN
        1 MPQPVGRKST ALPSPVVPPQ ANASALRRVL RRARDGVTLN VDEAAIAMTA RGDELADLCA
       61 SAARVRDAGL VSAGRHGPSG RLAISYSRKV FIPVTRLCRD NCHYCTFVTV PGKLRAQGSS
      121 TYMEPDEILD VARRGAEFGC KEALFTLGDR PEARWRQARE WLGERGYDST LSYVRAMAIR
      181 VLEQTGLLPH LNPGVMSWSE MSRLKPVAPS MGMMLETTSR RLFETKGLAH YGSPDKDPAV
      241 RLRVLTDAGR LSIPFTTGLL VGIGETLSER ADTLHAIRKS HKEFGHIQEV IVQNFRAKEH
      301 TAMAAFPDAG IEDYLATVAV ARLVLGPGMR IQAPPNLVSG DECRALVGAG VDDWGGVSPL
      361 TPDHVNPERP WPALDELAAV TAEAGYDMVQ RLTAQPKYVQ AGAAWIDPRV RGHVVALADP
      421 ATGLARDVNP VGMPWQEPDD VASWGRVDLG AAIDTQGRNT AVRSDLASAF GDWESIREQV
      481 HELAVRAPER IDTDVLAALR SAERAPAGCT DGEYLALATA DGPALEAVAA LADSLRRDVV
      541 GDEVTFVVNR NINFTNICYT GCRFCAFAQR KGDADAYSLS VGEVADRAWE AHVAGATEVC
      601 MQGGIDPELP VTGYADLVRA VKARVPSMHV HAFSPMEIAN GVTKSGLSIR EWLIGLREAG
      661 LDTIPGTAAE ILDDEVRWVL TKGKLPTSLW IEIVTTAHEV GLRSSSTMMY GHVDSPRHWV
      721 AHLNVLRDIQ DRTGGFTEFV PLPFVHQNSP LYLAGAARPG PSHRDNRAVH ALARIMLHGR
      781 ISHIQTSWVK LGVRRTQVML EGGANDLGGT LMEETISRMA GSEHGSAKTV AELVAIAEGI
      841 GRPARQRTTT YALLAA
//