LOCUS       SIT99776.1               250 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE protein.
ACCESSION   LT708304-1188
PROTEIN_ID  SIT99776.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB1176"
                     /note="Mb1176, -, len: 250 aa. Equivalent to Rv1144, len:
                     250 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100% identity in 250 aa overlap). Probable short-chain
                     dehydrogenase/reductase (EC 1.-.-.-), highly similar to
                     various dehydrogenases e.g. NP_104056.1|NC_002678
                     3-hydroxyacyl-CoA dehydrogenase type II from Mesorhizobium
                     loti (253 aa); NP_251244.1|NC_002516 probable short-chain
                     dehydrogenase from Pseudomonas aeruginosa (255 aa);
                     AAK15008.1|AF233685_1|AF233685 short chain
                     L-3-hydroxyacyl-CoA dehydrogenase from Mus musculus (261
                     aa); HSU73514|g1778354|XH98G2 human short-chain alcohol
                     dehydrogenase from Homo sapiens (261 aa), FASTA scores:
                     opt: 875, E(): 0, (60.1% identity in 253 aa overlap); etc.
                     Contains PS00061 Short-chain dehydrogenases/reductases
                     family signature. BELONGS TO THE SHORT-CHAIN
                     DEHYDROGENASES/REDUCTASES (SDR) FAMILY. Protein product
                     from Mb1176 detected using shotgun mass spectrometry and
                     SWATH mass spectrometry. Mb1176 found to be expressed
                     during exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3XXH8"
                     /db_xref="InterPro:IPR002347"
                     /db_xref="InterPro:IPR020904"
                     /db_xref="InterPro:IPR036291"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XXH8"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MKTKDAVAVV TGGASGLGLA TTKRLLDAGA QVVVVDLRGD DVVGGLGDRA RFAQADVTDE
       61 AAVSNALELA DSLGPVRVVV NCAGTGNAIR VLSRDGVFPL AAFRKIVDIN LVGTFNVLRL
      121 GAERIAKTEP IGEERGVIIN TASVAAFDGQ IGQAAYSASK GGVVGMTLPI ARDLASKLIR
      181 VVTIAPGLFD TPLLASLPAE AKASLGQQVP HPSRLGNPDE YGALVLHIIE NPMLNGEVIR
      241 LDGAIRMAPR
//