LOCUS       SIT99754.1               302 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE
            PEROXIDASE BPOB (NON-HAEM PEROXIDASE) protein.
ACCESSION   LT708304-1166
PROTEIN_ID  SIT99754.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="bpoB"
                     /locus_tag="BQ2027_MB1154C"
                     /note="Mb1154c, bpoB, len: 302 aa. Equivalent to Rv1123c,
                     len: 302 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100% identity in 302 aa overlap). Possible bpoB,
                     peroxidase (non-haem peroxidase) (EC 1.11.1.-), with some
                     similarity to a range of enzymes from several organisms
                     including: DEH1_MORSP|Q01398 haloacetate dehalogenase (EC
                     3.8.1.3) from Moraxella sp. (294 aa), FASTA scores: opt:
                     201, E(): 2.1e-06, (35.8% identity in 134 aa overlap); and
                     BPA1_STRAU|P33912 non-haem bromoperoxidase bpo-a1 (EC
                     1.11.1.-) from Streptomyces aureofaciens (274 aa), FASTA
                     scores: opt: 187, E(): 1.6e-05, (23.1% identity in 281 aa
                     overlap). Similar to several other Mycobacterium
                     tuberculosis proteins, probable epoxide hydrolases and
                     non-heme bromoperoxidases e.g. Rv1938, Rv3617, Rv3473c,
                     Rv3171c, etc. Contains PS00216 Sugar transport proteins
                     signature 1. Protein product from Mb1154c detected using
                     SWATH mass spectrometry. Mb1154c found to be expressed
                     during exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3XXG7"
                     /db_xref="InterPro:IPR000073"
                     /db_xref="InterPro:IPR029058"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XXG7"
BEGIN
        1 MTIWRVPSKV TSGPVSAVSS SPQAVAFSGA RGITLVADEW NRGAAAADRP TILMLHGGGQ
       61 NRFSWKNTGQ ILADEGHHVV ALDTRGPGDS DRAPGADYAV ETPTTDVLHV VEAIGRRVVV
      121 VEASMGGLTG ILVAERAGPQ TVNGLVLVDV VPRYEKEGNA RIRDFMLGNI DGFGSLEEAA
      181 DAVAEYLPHR DKPRSPEGLK RNLRLRDGRW HWHWDPAMMT APGHDPQLRT ENFERAAMGL
      241 TIPVLLIRGK LSDVVSSDGA RDFLAKVPNA EFVELSNAGR TAAGDDNDAF TDVVVDFVRR
      301 LS
//