LOCUS SIT99754.1 302 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE PEROXIDASE BPOB (NON-HAEM PEROXIDASE) protein. ACCESSION LT708304-1166 PROTEIN_ID SIT99754.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="bpoB" /locus_tag="BQ2027_MB1154C" /note="Mb1154c, bpoB, len: 302 aa. Equivalent to Rv1123c, len: 302 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 302 aa overlap). Possible bpoB, peroxidase (non-haem peroxidase) (EC 1.11.1.-), with some similarity to a range of enzymes from several organisms including: DEH1_MORSP|Q01398 haloacetate dehalogenase (EC 3.8.1.3) from Moraxella sp. (294 aa), FASTA scores: opt: 201, E(): 2.1e-06, (35.8% identity in 134 aa overlap); and BPA1_STRAU|P33912 non-haem bromoperoxidase bpo-a1 (EC 1.11.1.-) from Streptomyces aureofaciens (274 aa), FASTA scores: opt: 187, E(): 1.6e-05, (23.1% identity in 281 aa overlap). Similar to several other Mycobacterium tuberculosis proteins, probable epoxide hydrolases and non-heme bromoperoxidases e.g. Rv1938, Rv3617, Rv3473c, Rv3171c, etc. Contains PS00216 Sugar transport proteins signature 1. Protein product from Mb1154c detected using SWATH mass spectrometry. Mb1154c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:A0A1R3XXG7" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="UniProtKB/TrEMBL:A0A1R3XXG7" BEGIN 1 MTIWRVPSKV TSGPVSAVSS SPQAVAFSGA RGITLVADEW NRGAAAADRP TILMLHGGGQ 61 NRFSWKNTGQ ILADEGHHVV ALDTRGPGDS DRAPGADYAV ETPTTDVLHV VEAIGRRVVV 121 VEASMGGLTG ILVAERAGPQ TVNGLVLVDV VPRYEKEGNA RIRDFMLGNI DGFGSLEEAA 181 DAVAEYLPHR DKPRSPEGLK RNLRLRDGRW HWHWDPAMMT APGHDPQLRT ENFERAAMGL 241 TIPVLLIRGK LSDVVSSDGA RDFLAKVPNA EFVELSNAGR TAAGDDNDAF TDVVVDFVRR 301 LS //