LOCUS       SIT99740.1               335 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            LYTB-RELATED PROTEIN LYTB2 protein.
ACCESSION   LT708304-1152
PROTEIN_ID  SIT99740.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="lytB2"
                     /locus_tag="BQ2027_MB1140"
                     /note="Mb1140, lytB2, len: 335 aa. Equivalent to Rv1110,
                     len: 335 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100% identity in 335 aa overlap). Probable lytB2,
                     LytB-related protein, equivalent to AL049491|MLCB1222_3
                     from Mycobacterium leprae (335 aa), FASTA score: (82.9%
                     identity in 333 aa overlap). Also similar to LytB proteins
                     from many bacteria (appears to have N-terminal extension)
                     e.g. P22565|LYTB_ECOLI|B0029|Z0034|ECS0032 LYTB PROTEIN
                     from Escherichia coli strains K12 and O157:H7 (316 aa),
                     FASTA scores: opt: 1041, E():0, (52.4% identity in 309 aa
                     overlap); etc. Also very similar to another LytB-related
                     protein from Mycobacterium tuberculosis:
                     LytB1|Rv3382c|MTV004.40c (329 aa), FASTA scores: opt: 975,
                     E(): 0, (51.3% identity in 312 aa overlap). BELONGS TO THE
                     LYTB FAMILY. Protein product from Mb1140 detected using
                     shotgun mass spectrometry and SWATH mass spectrometry.
                     Mb1140 found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing."
                     /db_xref="GOA:P0A5I1"
                     /db_xref="InterPro:IPR003451"
                     /db_xref="UniProtKB/Swiss-Prot:P0A5I1"
BEGIN
        1 MVPTVDMGIP GASVSSRSVA DRPNRKRVLL AEPRGYCAGV DRAVETVERA LQKHGPPVYV
       61 RHEIVHNRHV VDTLAKAGAV FVEETEQVPE GAIVVFSAHG VAPTVHVSAS ERNLQVIDAT
      121 CPLVTKVHNE ARRFARDDYD ILLIGHEGHE EVVGTAGEAP DHVQLVDGVD AVDQVTVRDE
      181 DKVVWLSQTT LSVDETMEIV GRLRRRFPKL QDPPSDDICY ATQNRQVAVK AMAPECELVI
      241 VVGSRNSSNS VRLVEVALGA GARAAHLVDW ADDIDSAWLD GVTTVGVTSG ASVPEVLVRG
      301 VLERLAECGY DIVQPVTTAN ETLVFALPRE LRSPR
//