LOCUS       SIT99738.1               415 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            EXODEOXYRIBONUCLEASE VII (LARGE SUBUNIT) XSEA (EXONUCLEASE
            VII LARGE SUBUNIT) protein.
ACCESSION   LT708304-1150
PROTEIN_ID  SIT99738.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="xseA"
                     /locus_tag="BQ2027_MB1138C"
                     /note="Mb1138c, xseA, len: 415 aa. Equivalent to Rv1108c,
                     len: 415 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100% identity in 415 aa overlap). Probable xseA,
                     exodeoxyribonuclease VII large subunit (EC 3.1.11.6) (see
                     first citation below). Equivalent to AL049491|MLCB1222_5
                     Mycobacterium leprae (428 aa) (81.5% identity in 411 aa
                     overlap). Similar to many e.g. P04994|EX7L_ECOLI
                     exodeoxyribonuclease large subunit from Escherichia coli
                     (456 aa), FASTA scores: opt: 581, E(): 1.6 e-30, (30.8%
                     identity in 425 aa overlap); also similar to the
                     exodeoxyribonuclease in Bacillus subtilis, H. influenzae
                     and H. pylori. TBparse score is 0.890. BELONGS TO THE XSEA
                     FAMILY. Protein product from Mb1138c detected using
                     shotgun mass spectrometry and SWATH mass spectrometry.
                     Mb1138c found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing."
                     /db_xref="GOA:P67448"
                     /db_xref="InterPro:IPR003753"
                     /db_xref="InterPro:IPR020579"
                     /db_xref="InterPro:IPR025824"
                     /db_xref="UniProtKB/Swiss-Prot:P67448"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MTQNSAENPF PVRAVAIRVA GWIDKLGAVW VEGQLAQITM RPDAKTVFMV LRDPAADMSL
       61 TVTCSRDLVL SAPVKLAEGV QVVVCGKPSF YTGRGTFSLR LSEIRAVGIG ELLARIDRLR
      121 RLLDAEGLFD PRLKRPIPYL PNMIGLITGR ASAAERDVTT VASARWPAAR FAVRNVAVQG
      181 PNAVGQIVEA LRELDRDPDV DVIVLARGGG SVEDLLPFSD ETLCRAIAAC RTPVVSAVGH
      241 EPDNPLCDLV VDLRAATPTD AAKKVVPDTA AEQRLIDDLR RRSAQALRNW VSREQRAVAQ
      301 LRSRPVLADP MTMVSVRAEE VHRARSTLRR NLTLMVAAET ERIGHLAARL ATLGPAATLA
      361 RGYAIVQTVA QTGPEGGSEP QVLRSVHDAP EGTKLRVRVA DGALAAVSEG QTNGL
//