LOCUS       SIT99726.1               291 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE
            GLYCOSYL HYDROLASE protein.
ACCESSION   LT708304-1138
PROTEIN_ID  SIT99726.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB1126"
                     /note="Mb1126, -, len: 291 aa. Equivalent to Rv1096, len:
                     291 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.7% identity in 291 aa overlap). Possible glycosyl
                     hydrolase (EC 3.-.-.-), possibly a deacetylase or
                     esterase. Equivalent to AL049491|MLCB1222_13 Mycobacterium
                     leprae (291 aa) (81.3% identity in 289 aa overlap).
                     Similar at the C-terminus of enzymes involved in
                     carbohydrate degradation including Z99110|BSUB0007_92
                     endo-1,4-beta-xylanase homolog yjeA from Bacillus subtilis
                     (467 aa), FASTA scores: opt: 418, E(): 2.6e-17, (38.6%
                     identity in 184 aa overlap); M64552|STMXLNB_2 acetyl-xylan
                     esterase from Streptomyces lividans (335 aa), FASTA
                     scores: opt: 371, E(): 1.1e-14, (31.6% identity in 237 aa
                     overlap); NP_345933.1|NC_003028 peptidoglycan
                     N-acetylglucosamine deacetylase A from Streptococcus
                     pneumoniae (463 aa); etc. Has possible N-terminal signal
                     sequence with TMhelix at aa 13-31. Protein product from
                     Mb1126 detected using shotgun mass spectrometry and SWATH
                     mass spectrometry. Mb1126 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3XXC7"
                     /db_xref="InterPro:IPR002509"
                     /db_xref="InterPro:IPR011330"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XXC7"
BEGIN
        1 MPKRPDNQTW RYWRTVTGVV VAGAVLVVGG LSGRVTRAEN LSCSVIKCVA LTFDDGPGPY
       61 TDRLLHILTD NDAKATFFLI GNKVAANPAG ARRIADAGME IGSHTWEHPN MTTIPPEDIP
      121 GQFSRANDVI AAATGRTPTL YRPAGGLSND AVRQAAAKVG QAEILWDVIP FDWINDSNTA
      181 ATRHMLMTQI KPGSVVLFHD TYSSTVDVVY QFIPVLKANG YRLVTVSELL GPRAPGSSYG
      241 SRENGPPVNE LRDIPASEIP PLPNTSSPKP MSNFPITDIA GQNSGGPNNG A
//