LOCUS       SIT99710.1               288 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 Mycothiol
            conjugate amidase Mca (Mycothiol S-conjugate amidase)
            protein.
ACCESSION   LT708304-1122
PROTEIN_ID  SIT99710.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="mca"
                     /locus_tag="BQ2027_MB1111"
                     /note="Mb1111, mca, len: 288 aa. Equivalent to Rv1082,
                     len: 288 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100% identity in 288 aa overlap). mca, mycothiol
                     conjugate amidase (see citation below), equivalent to
                     NP_302547.1|NC_002677 conserved hypothetical protein from
                     Mycobacterium leprae (290 aa), FASTA scores: opt: 1737,
                     E(): 0, (86.4% identity in 287 aa overlap); and similar to
                     Q54358|X79146 lmbE protein from Streptomyces lincolnensis
                     (270 aa). Also similar to Rv1170|MTV005.06|MSHB GlcNAc-Ins
                     deacetylase from Mycobacterium tuberculosis (303 aa),
                     FASTA scores: opt: 411, E(): 9.4e-20, (35.8% identity in
                     299 aa overlap). Protein product from Mb1111 detected
                     using shotgun mass spectrometry and SWATH mass
                     spectrometry. Mb1111 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3XXA8"
                     /db_xref="InterPro:IPR003737"
                     /db_xref="InterPro:IPR017811"
                     /db_xref="InterPro:IPR024078"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XXA8"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MSELRLMAVH AHPDDESSKG AATLARYADE GHRVLVVTLT GGERGEILNP AMDLPDVHGR
       61 IAEIRRDEMT KAAEILGVEH TWLGFVDSGL PKGDLPPPLP DDCFARVPLE VSTEALVRVV
      121 REFRPHVMTT YDENGGYPHP DHIRCHQVSV AAYEAAGDFC RFPDAGEPWT VSKLYYVHGF
      181 LRERMQMLQD EFARHGQRGP FEQWLAYWDP DHDFLTSRVT TRVECSKYFS QRDDALRAHA
      241 TQIDPNAEFF AAPLAWQERL WPTEEFELAR SRIPARPPET ELFAGIEP
//