LOCUS SIT99677.1 148 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE TRANSCRIPTIONAL REPRESSOR PROTEIN protein. ACCESSION LT708304-1089 PROTEIN_ID SIT99677.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB1078" /note="Mb1078, -, len: 148 aa. Equivalent to Rv1049, len: 148 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 148 aa overlap). Probable transcriptional repressor protein, similar to many e.g. P74870 NEGATIVE REGULATOR OF EMR LOCUS EMR from Salmonella typhimurium (149 aa), FASTA scores: opt: 146, E(): 0.0011, (31.6% identity in 95 aa overlap). Contains probable helix-turn -helix motif at aa 58-79 (Score 1495, +4.28 SD). Mb1078 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing (TPM > 20)." /db_xref="GOA:A0A1R3XX75" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/TrEMBL:A0A1R3XX75" BEGIN 1 MGKGAAFDEC ACYTTRRAAR QLGQAYDRAL RPSGLTNTQF STLAVISLSE GSAGIDLTMS 61 ELAARIGVER TTLTRNLEVM RRDGLVRVMA GADARCKRIE LTAKGRAALQ KAVPLWRGVQ 121 AEVTASVGDW PRVRRDIANL GQAAEACR //