LOCUS       SIT99677.1               148 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            TRANSCRIPTIONAL REPRESSOR PROTEIN protein.
ACCESSION   LT708304-1089
PROTEIN_ID  SIT99677.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB1078"
                     /note="Mb1078, -, len: 148 aa. Equivalent to Rv1049, len:
                     148 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100% identity in 148 aa overlap). Probable
                     transcriptional repressor protein, similar to many e.g.
                     P74870 NEGATIVE REGULATOR OF EMR LOCUS EMR from Salmonella
                     typhimurium (149 aa), FASTA scores: opt: 146, E(): 0.0011,
                     (31.6% identity in 95 aa overlap). Contains probable
                     helix-turn -helix motif at aa 58-79 (Score 1495, +4.28
                     SD). Mb1078 found to be expressed during exponential
                     growth in Sauton's minimal media by RNA-sequencing (TPM >
                     20)."
                     /db_xref="GOA:A0A1R3XX75"
                     /db_xref="InterPro:IPR000835"
                     /db_xref="InterPro:IPR036388"
                     /db_xref="InterPro:IPR036390"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XX75"
BEGIN
        1 MGKGAAFDEC ACYTTRRAAR QLGQAYDRAL RPSGLTNTQF STLAVISLSE GSAGIDLTMS
       61 ELAARIGVER TTLTRNLEVM RRDGLVRVMA GADARCKRIE LTAKGRAALQ KAVPLWRGVQ
      121 AEVTASVGDW PRVRRDIANL GQAAEACR
//