LOCUS       SIT99645.1               495 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 Probable
            UDP-N-acetylglucosamine pyrophosphorylase glmU protein.
ACCESSION   LT708304-1057
PROTEIN_ID  SIT99645.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="glmU"
                     /locus_tag="BQ2027_MB1046C"
                     /note="Mb1046c, glmU, len: 495 aa. Equivalent to Rv1018c,
                     len: 495 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.6% identity in 495 aa overlap). Probable glmU,
                     UDP-n-acetylglucosamine pyrophosphorylase (EC 2.7.7.23),
                     similar to GCAD_BACSU|P14192 UDP-n-acetylglucosamine
                     pyrophosphorylase (456 aa), FASTA scores: opt: 1150, E():
                     0, (40.0% identity in 453 aa overlap). Similar to various
                     Mycobacterium tuberculosis sugar-phosphate transferases
                     e.g. Rv0334, Rv1213, Rv3264c, etc. Protein product from
                     Mb1046c detected using shotgun mass spectrometry and SWATH
                     mass spectrometry. Mb1046c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:Q7VF00"
                     /db_xref="InterPro:IPR001451"
                     /db_xref="InterPro:IPR005882"
                     /db_xref="InterPro:IPR011004"
                     /db_xref="InterPro:IPR025877"
                     /db_xref="InterPro:IPR029044"
                     /db_xref="InterPro:IPR038009"
                     /db_xref="UniProtKB/Swiss-Prot:Q7VF00"
BEGIN
        1 MTFPGDTAVL VLAAGPGTRM RSDTPKVLHT LAGRSMLSHV LHAIAKLAPQ RLIVVLGHDH
       61 QRIAPLVGEL ADTLGRTIDV ALQDRPLGTG HAVLCGLSAL PDDYAGNVVV TSGDTPLLDA
      121 DTLADLIATH RAVSAAVTVL TTTLDDPFGY GRILRTQDHG VMAIVEQTDA TPSQREIREV
      181 NAGVYAFDIA ALRSALSRLS SNNAQQELYL TDVIAILRSD GQTVHASHVD DSALVAGVNN
      241 RVQLAQLASE LNRRVVAAHQ LAGVTVVDPA TTWIDVDVTI GRDTVIHPGT QLLGRTQIGG
      301 RCVVGPDTTL TDVAVGDGAS VVRTHGSSSS IGDGAAVGPF TYLRPGTALG ADGKLGAFVE
      361 VKNSTIGTGT KVPHLTYVGD ADIGEYSNIG ASSVFVNYDG TSKRRTTVGS HVRTGSDTMF
      421 VAPVTIGDGA YTGAGTVVRE DVPPGALAVS AGPQRNIENW VQRKRPGSPA AQASKRASEM
      481 ACQQPTQPPD ADQTP
//