LOCUS       SIT99634.1               519 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 methionyl-
            trna synthetase mets (metrs) (methionine--trna ligase)
            protein.
ACCESSION   LT708304-1046
PROTEIN_ID  SIT99634.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="metS"
                     /locus_tag="BQ2027_MB1034C"
                     /note="Mb1034c, metS, len: 519 aa. Equivalent to Rv1007c,
                     len: 519 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.8% identity in 519 aa overlap). Probable metS (MetG),
                     methionyl-tRNA synthetase (EC 6.1.1.10), similar to many
                     e.g. SYM_BACSU|P37465 methionyl-tRNA synthetase from
                     Bacillus subtilus (664 aa), FASTA scores: opt: 1506, E():
                     0, (44.9% identity in 492 aa overlap); similar to other M.
                     tuberculosis tRNA synthases e.g. Rv2448c, Rv1536, Rv0041.
                     Contains PS00178 Aminoacyl-transfer RNA synthetases
                     class-I signature. BELONGS TO CLASS-I AMINOACYL-TRNA
                     SYNTHETASE FAMILY. STRONG, TO CYSTEINYL-TRNA SYNTHETASE.
                     Protein product from Mb1034c detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb1034c found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
                     /db_xref="GOA:P59952"
                     /db_xref="InterPro:IPR001412"
                     /db_xref="InterPro:IPR009080"
                     /db_xref="InterPro:IPR014729"
                     /db_xref="InterPro:IPR014758"
                     /db_xref="InterPro:IPR015413"
                     /db_xref="InterPro:IPR023457"
                     /db_xref="InterPro:IPR033911"
                     /db_xref="InterPro:IPR041872"
                     /db_xref="UniProtKB/Swiss-Prot:P59952"
BEGIN
        1 MKPYYVTTAI AYPNAAPHVG HAYEYIATDA IARFKRLDGY DVRFLTGTDE HGLKVAQAAA
       61 AAGVPTAALA RRNSDVFQRM QEALNISFDR FIRTTDADHH EASKELWRRM SAAGDIYLDN
      121 YSGWYSVRDE RFFVESETQL VDGTRLTVET GTPVTWTEEQ TYFFRLSAYT DKLLAHYHAN
      181 PDFIAPETRR NEVISFVSGG LDDLSISRTS FDWGVQVPEH PDHVMYVWVD ALTNYLTGAG
      241 FPDTDSELFR RYWPADLHMI GKDIIRFHAV YWPAFLMSAG IELPRRIFAH GFLHNRGEKM
      301 SKSVGNIVDP VALAEALGVD QVRYFLLREV PFGQDGSYSD EAIVTRINTD LANELGNLAQ
      361 RSLSMVAKNL DGRVPNPGEF ADADAALLAT ADGLLERVRG HFDAQAMHLA LEAIWLMLGD
      421 ANKYFSVQQP WVLRKSESEA DQARFRTTLY VTCEVVRIAA LLIQPVMPES AGKILDLLGQ
      481 APNQRSFAAV GVRLTPGTAL PPPTGVFPRY QPPQPPEGK
//