LOCUS SIT99632.1 478 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 Probable para-aminobenzoate synthase component I PABD protein. ACCESSION LT708304-1044 PROTEIN_ID SIT99632.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="pabB" /locus_tag="BQ2027_MB1032C" /note="Mb1032c, pabB, len: 478 aa. Similar to Rv1005c, len: 458 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 458 aa overlap). Probable PabD, para-aminobenzoate synthase component I (EC 4.1.3.-). Similar to PABB_ECOLI|P05041 para-aminobenzoate synthase component I from Escherichia coli (453 aa), FASTA scores: opt: 589, E(): 1.8e-27, (40.7% identity in 268 aa overlap). Similar to Mycobacterium tuberculosis Rv1609, Rv3215, Rv2386c. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base transition (g-a) leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (478 aa versus 458 aa). Mb1032c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing (TPM > 20)." /db_xref="GOA:A0A1R3XZ71" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR005802" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR019999" /db_xref="UniProtKB/TrEMBL:A0A1R3XZ71" BEGIN 1 MALAARTATP PGTETGAGHG SNLAWELSTR TKSPRSHLRC ENPQFCQART VRIDRLGDLG 61 GAPAVLRAVG RATSRLDLPP PAALTGEWFG ALAVIAPSVS IQPVSGDDVF SGPPGTGGPD 121 ATGAVGGGWV GYLSYPDAGA DGRPHRIPEA AGGWTDCVLR RDRDGQWWYE SLSGAPIADW 181 LASALATTRA SVARPAPACR IDWEPADRAA HRDGVLACLE AIGAGEVYQA CVCTQFAGTV 241 TGSPLDFFID GFGRTAPSRS AFVAGPWGAV ASLSPELFLR RRGSVVTSSP IKGTLPLDAP 301 PSALRASAKE VAENIMIVDL VRNDLGRVAV TGTVTVPELL VVRPAPGVWH LVSTVSARVP 361 LEEPMSALLD AAFPPASVTG TPKLRARQLI SQWERYRRGI YCGTVGLASP VAGCELNVAI 421 RTVEFDTAGN AVLGVGGGIT ADSDPDAEWA ECLHKAAPIV GLPAATRTTP ARLASKVR //