LOCUS       SIT99632.1               478 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 Probable
            para-aminobenzoate synthase component I PABD protein.
ACCESSION   LT708304-1044
PROTEIN_ID  SIT99632.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="pabB"
                     /locus_tag="BQ2027_MB1032C"
                     /note="Mb1032c, pabB, len: 478 aa. Similar to Rv1005c,
                     len: 458 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100% identity in 458 aa overlap). Probable PabD,
                     para-aminobenzoate synthase component I (EC 4.1.3.-).
                     Similar to PABB_ECOLI|P05041 para-aminobenzoate synthase
                     component I from Escherichia coli (453 aa), FASTA scores:
                     opt: 589, E(): 1.8e-27, (40.7% identity in 268 aa
                     overlap). Similar to Mycobacterium tuberculosis Rv1609,
                     Rv3215, Rv2386c. REMARK-M.bovis-M.tuberculosis: In
                     Mycobacterium bovis, a single base transition (g-a) leads
                     to a longer product compared to its homolog in
                     Mycobacterium tuberculosis strain H37Rv (478 aa versus 458
                     aa). Mb1032c found to be expressed during exponential
                     growth in Sauton's minimal media by RNA-sequencing (TPM >
                     20)."
                     /db_xref="GOA:A0A1R3XZ71"
                     /db_xref="InterPro:IPR005801"
                     /db_xref="InterPro:IPR005802"
                     /db_xref="InterPro:IPR015890"
                     /db_xref="InterPro:IPR019999"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XZ71"
BEGIN
        1 MALAARTATP PGTETGAGHG SNLAWELSTR TKSPRSHLRC ENPQFCQART VRIDRLGDLG
       61 GAPAVLRAVG RATSRLDLPP PAALTGEWFG ALAVIAPSVS IQPVSGDDVF SGPPGTGGPD
      121 ATGAVGGGWV GYLSYPDAGA DGRPHRIPEA AGGWTDCVLR RDRDGQWWYE SLSGAPIADW
      181 LASALATTRA SVARPAPACR IDWEPADRAA HRDGVLACLE AIGAGEVYQA CVCTQFAGTV
      241 TGSPLDFFID GFGRTAPSRS AFVAGPWGAV ASLSPELFLR RRGSVVTSSP IKGTLPLDAP
      301 PSALRASAKE VAENIMIVDL VRNDLGRVAV TGTVTVPELL VVRPAPGVWH LVSTVSARVP
      361 LEEPMSALLD AAFPPASVTG TPKLRARQLI SQWERYRRGI YCGTVGLASP VAGCELNVAI
      421 RTVEFDTAGN AVLGVGGGIT ADSDPDAEWA ECLHKAAPIV GLPAATRTTP ARLASKVR
//