LOCUS       SIT99619.1               306 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 utp-
            -glucose-1-phosphate uridylyltransferase galu (udp-glucose
            pyrophosphorylase) (udpgp) (alpha-d-glucosyl-1-phosphate
            uridylyltransferase) (uridine diphosphoglucose pyrophosphorylase)
            protein.
ACCESSION   LT708304-1031
PROTEIN_ID  SIT99619.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="galU"
                     /locus_tag="BQ2027_MB1020"
                     /note="Mb1020, galU, len: 306 aa. Equivalent to Rv0993,
                     len: 306 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.7% identity in 306 aa overlap). Probable galU,
                     UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9),
                     equivalent to AL035500|MLCL373_22 putative
                     UTP-glucose-1-phosphate uridylyltransferase from
                     Mycobacterium leprae (306 aa), FASTA score: (89.7%
                     identity in 302 aa overlap). Also highly similar to others
                     e.g. AB59678.1|AL132674 UTP-glucose-1-phosphate
                     uridylyltransferase from Streptomyces coelicolor (303 aa);
                     NP_244519.1|NC_002570 UTP-glucose-1-phosphate
                     uridylyltransferase from Bacillus halodurans (297 aa);
                     P25520|GALU_ECOLI|B1236|Z2012|ECS17
                     UTP--glucose-1-phosphate uridylyltransferase from
                     Escherichia coli strains K12 and O157:H7 (301 aa), FASTA
                     scores: opt: 624, E(): 2.4e-33, (38.8% identity in 299 aa
                     overlap); etc. BELONGS TO THE PROKARYOTIC UDPGP FAMILY.
                     Protein product from Mb1020 detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb1020 found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:A0A1R3XX25"
                     /db_xref="InterPro:IPR005771"
                     /db_xref="InterPro:IPR005835"
                     /db_xref="InterPro:IPR029044"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XX25"
BEGIN
        1 MSRPEVLTPF TAIVPAAGLG TRFLPATKTV PKELLPVVDT PGIELVAAEA AAAGAERLVI
       61 VTSEGKDGVV AHFVEDLVLE GTLEARGKIA MLAKVRRAPA LIKVESVVQA EPLGLGHAIG
      121 CVEPTLSPDE DAVAVLLPDD LVLPTGVLET MSKVRASRGG TVLCAIEVAR EEISAYGVFD
      181 VEPVPDGDYT DDPNVLKVRG MVEKPKAETA PSRYAAAGRY VLDRAIFDAL RRIDRGAGGE
      241 VQLTDAIALL IAEGHPVHVV VHQGSRHDLG NPGGYLKAAV DFALDRDDYG PDLRRWLVAR
      301 LGLTEQ
//