LOCUS SIT99612.1 423 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE ADHESION COMPONENT TRANSPORT TRANSMEMBRANE PROTEIN ABC TRANSPORTER protein. ACCESSION LT708304-1024 PROTEIN_ID SIT99612.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB1013" /note="Mb1013, -, len: 423 aa. Equivalent to 5' end of Rv0987, len: 855 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 423 aa overlap). Probable transmembrane protein ABC transporter supposed involved in transport of adhesion component (see citation below), whose N-terminus shows similarity with hypothetical proteins, generally transmembrane proteins, e.g. CAB96016.1|AL360055 putative ABC transport system integral membrane protein from Streptomyces coelicolor (855 aa); P44252|YCFU_HAEIN|HI1555 HYPOTHETICAL PROTEIN from Haemophilus influenzae (393 aa), FASTA scores: opt: 265, E(): 1.7e-09, (23.6% identity in 402 aa overlap); etc. N-and C-termini respectively show similarity to O32735 ATTF PROTEIN (420 aa), FASTA scores: E(): 1e-09, (26.7% identity in 430 aa overlap), and G2340078 ATTG PROTEIN (359 aa), FASTA scores: E(): 2.7e-08, (27.8% identity in 356 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0987 exists as a single gene. In Mycobacterium bovis, a single base transition (g-a) introduces a stop codon that splits Rv0987 in two parts, Mb1013 and Mb1014. Mb1013 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:A0A1R3XZ45" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="UniProtKB/TrEMBL:A0A1R3XZ45" BEGIN 1 MNDQAPVAYA PLWRTAWRRL RQRPFQYILL VLGIALGVAM IVAIDVSSNS AQRAFDLSAA 61 AITGKSTHRL VSGPAGVDQQ LYVDLRRHGY DFSAPVIEGY VLARGLGNRA MQFMGTDPFA 121 ESAFRSPLWS NQNIAELGGF LTRPNGVVLS RQVAQKYGLA VGDRIALQVK GAPTTVTLVG 181 LLTPADEVSN QKLSDLIIAD ISTAQELFHM PGRLSHIDLI IKDEATATRI QQRLPAGVRM 241 ETSDTQRDTV KQMTDAFTVN LTALSLIALL VGIFLIYNTV TFNVVQRRPF FAILRCLGVT 301 REQLFWLIMT ESLVAGLIGT GLGLLIGIWL GEGLIGLVTQ TINDFYFVIN VRNVSVSAES 361 LLKGLIIGIF AAMLATLPPA IEAMRTVPAS TLRRSSLESK ITKLMPWLWV AWFGLGSFGV 421 LML //