LOCUS       SIT99612.1               423 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            ADHESION COMPONENT TRANSPORT TRANSMEMBRANE PROTEIN ABC
            TRANSPORTER protein.
ACCESSION   LT708304-1024
PROTEIN_ID  SIT99612.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB1013"
                     /note="Mb1013, -, len: 423 aa. Equivalent to 5' end of
                     Rv0987, len: 855 aa, from Mycobacterium tuberculosis
                     strain H37Rv, (100% identity in 423 aa overlap). Probable
                     transmembrane protein ABC transporter supposed involved in
                     transport of adhesion component (see citation below),
                     whose N-terminus shows similarity with hypothetical
                     proteins, generally transmembrane proteins, e.g.
                     CAB96016.1|AL360055 putative ABC transport system integral
                     membrane protein from Streptomyces coelicolor (855 aa);
                     P44252|YCFU_HAEIN|HI1555 HYPOTHETICAL PROTEIN from
                     Haemophilus influenzae (393 aa), FASTA scores: opt: 265,
                     E(): 1.7e-09, (23.6% identity in 402 aa overlap); etc.
                     N-and C-termini respectively show similarity to O32735
                     ATTF PROTEIN (420 aa), FASTA scores: E(): 1e-09, (26.7%
                     identity in 430 aa overlap), and G2340078 ATTG PROTEIN
                     (359 aa), FASTA scores: E(): 2.7e-08, (27.8% identity in
                     356 aa overlap). Contains PS00017 ATP/GTP-binding site
                     motif A (P-loop). REMARK-M.bovis-M.tuberculosis: In
                     Mycobacterium tuberculosis strain H37Rv, Rv0987 exists as
                     a single gene. In Mycobacterium bovis, a single base
                     transition (g-a) introduces a stop codon that splits
                     Rv0987 in two parts, Mb1013 and Mb1014. Mb1013 found to be
                     expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
                     /db_xref="GOA:A0A1R3XZ45"
                     /db_xref="InterPro:IPR003838"
                     /db_xref="InterPro:IPR025857"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XZ45"
BEGIN
        1 MNDQAPVAYA PLWRTAWRRL RQRPFQYILL VLGIALGVAM IVAIDVSSNS AQRAFDLSAA
       61 AITGKSTHRL VSGPAGVDQQ LYVDLRRHGY DFSAPVIEGY VLARGLGNRA MQFMGTDPFA
      121 ESAFRSPLWS NQNIAELGGF LTRPNGVVLS RQVAQKYGLA VGDRIALQVK GAPTTVTLVG
      181 LLTPADEVSN QKLSDLIIAD ISTAQELFHM PGRLSHIDLI IKDEATATRI QQRLPAGVRM
      241 ETSDTQRDTV KQMTDAFTVN LTALSLIALL VGIFLIYNTV TFNVVQRRPF FAILRCLGVT
      301 REQLFWLIMT ESLVAGLIGT GLGLLIGIWL GEGLIGLVTQ TINDFYFVIN VRNVSVSAES
      361 LLKGLIIGIF AAMLATLPPA IEAMRTVPAS TLRRSSLESK ITKLMPWLWV AWFGLGSFGV
      421 LML
//