LOCUS       SIT99609.1               181 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE
            PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE MOAB2 (PHS) (
            4-ALPHA-HYDROXY-TETRAHYDROPTERIN DEHYDRATASE) (PTERIN-
            4-A-CARBINOLAMINE DEHYDRATASE) (PHENYLALANINE HYDROXYLASE-
            STIMULATING PROTEIN) (PHS) (PTERIN CARBINOLAMINE DEHYDRATASE)
            (PCD) protein.
ACCESSION   LT708304-1021
PROTEIN_ID  SIT99609.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="moaB2"
                     /locus_tag="BQ2027_MB1010"
                     /note="Mb1010, moaB2, len: 181 aa. Equivalent to Rv0984,
                     len: 181 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100% identity in 181 aa overlap). Possible moaB2,
                     pterin-4-alpha-carbinolamine dehydratase (EC 4.2.1.96),
                     highly similar to NP_301253.1|NC_002677 putative
                     molybdenum cofactor biosynthesis protein from
                     Mycobacterium leprae (181 aa), FASTA score: (92.3%
                     identity in 181 aa overlap). Also similar to others e.g.
                     CAB59675.1|AL132674 molybdenum cofactor biosynthesis
                     protein from Streptomyces coelicolor (179 aa);
                     Q56208|MOCB_SYNP7 MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN
                     CB from Synechococcus sp. (319 aa), FASTA score: (37.3%
                     identity in 142 aa overlap); C-terminus of
                     NP_197599.1|NC_003076 MOLYBDOPTERIN BIOSYNTHESIS CNX1
                     PROTEIN from Arabidopsis thaliana (670 aa); etc. Also
                     similar to Rv0865|MOG from Mycobacterium tuberculosis (160
                     aa); and other mog proteins e.g. CAC39235.1|AJ312124 Mog
                     protein from Eubacterium acidaminophilum (162 aa). COULD
                     BELONG TO THE PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE
                     FAMILY. Alternative start codon has been suggested in
                     position 1100508. Protein product from Mb1010 detected
                     using shotgun mass spectrometry. Mb1010 found to be
                     expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
                     /db_xref="InterPro:IPR001453"
                     /db_xref="InterPro:IPR036425"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XX15"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MKVAAQCSKL GYTVAPMEQR AELVVGRALV VVVDDRTAHG DEDHSGPLVT ELLTEAGFVV
       61 DGVVAVSADE VEIRNALNTA VIGGVDLVVS VGGTGVTPRD VTPEATRDIL DREILGIAEA
      121 IRASGLSAGI VDAGLSRGLA GVSGSTLVVN LAGSRYAVRD GMATLNPLAA QIIGQLSSLE
      181 I
//