LOCUS SIT99607.1 504 aa PRT BCT 25-MAY-2020
DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 two
component sensor kinase mprb protein.
ACCESSION LT708304-1019
PROTEIN_ID SIT99607.1
SOURCE Mycobacterium tuberculosis variant bovis AF2122/97
ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Malone K.M.
JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary
Medicine, Tuberculosis Molecular Microbiology Research Group,
University College Dublin, Tuberculosis Molecular Microbiology
Research Group, School of Veterinary Medicine, University College
Dublin, D4, Ireland
REFERENCE 2
AUTHORS Malone M K., Farrell D., Malone K.
JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary
Medicine, Tuberculosis Molecular Microbiology Research Group,
University College Dublin, Tuberculosis Molecular Microbiology
Research Group, School of Veterinary Medicine,, University College
Dublin, D4, Ireland
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis variant bovis
AF2122/97"
/chromosome="Mycobacterium_bovis_AF212297"
/isolate="AF2122/97"
/mol_type="genomic DNA"
/isolation_source="Mycobacterium bovis subsp. bovis strain
AF2122/97. This strain is a fully virulent strain that was
isolated in 1997 in the UK from a cow suffering necrotic
lesions in lung and bronchomediastinal lymph nodes. The
strain was also reported to infect and persist in badgers
that are considered to be a significant source of bovine
infection."
/db_xref="taxon:233413"
protein /transl_table=11
/gene="mprB"
/locus_tag="BQ2027_MB1008"
/note="Mb1008, mprB, len: 504 aa. Equivalent to Rv0982,
len: 504 aa, from Mycobacterium tuberculosis strain H37Rv,
(99.8% identity in 504 aa overlap). Probable mprB, two
component sensor kinase, transmembrane protein (EC
2.7.3.-) (see citation below), equivalent to
AL035500|MLCL373_16|NP_301251.1|NC_002677 putative
two-component system sensor kinase from Mycobacterium
leprae (519 aa), FASTA score: (81.0% identity in 521 aa
overlap). Also highly similar to others (especially in
C-terminal part) e.g. AAG36760.1|AF119221_2|AF119221
sensor kinase from Corynebacterium glutamicum (455 aa);
CAB89748.1|AL354616 putative two-component histidine
kinase from Streptomyces coelicolor (481 aa);
X58793|SLCUTRS_2 sensor kinase from S.lividans (414 aa),
FASTA scores: opt: 451, E(): 4.2e-21, (36.0% identity in
303 aa overlap); P30847|BAES_ECOLI SENSOR PROTEIN (EC
2.7.3.-) from Escherichia coli (467 aa), FASTA scores:
opt: 412, E(): 1.3e-18, (30.4% identity in 336 aa
overlap); etc. Also similar in C-terminal region to
C-terminus of Rv0902c|Z73101|MTCY31_33 from Mycobacterium
tuberculosis (446 aa), FASTA scores: opt: 423, E():
2.6e-19, (28.4 identity in 462 aa overlap). Protein
product from Mb1008 detected using shotgun mass
spectrometry and SWATH mass spectrometry. Mb1008 found to
be expressed during exponential growth in Sauton's minimal
media by RNA-sequencing."
/db_xref="GOA:Q7U0X3"
/db_xref="InterPro:IPR003594"
/db_xref="InterPro:IPR003660"
/db_xref="InterPro:IPR003661"
/db_xref="InterPro:IPR004358"
/db_xref="InterPro:IPR005467"
/db_xref="InterPro:IPR036097"
/db_xref="InterPro:IPR036890"
/db_xref="UniProtKB/Swiss-Prot:Q7U0X3"
BEGIN
1 MWWFRRRDRA PLRATSSLSL RWRVMLLAMS MVAMVVVLMS FAVYAVISAA LYSDIDNQLQ
61 SRAQLLIASG SLAADPGKAI EGTAYSDVNA MLVNPGQSIY TAQQPGQTLP VGAAEKAVIR
121 GELFMSRRTT ADQRVLAIRL TNGSSLLISK SLKPTEAVMN KLRWVLLIVG GIGVAVAAVA
181 GGMVTRAGLR PVGRLTEAAE RVARTDDLRP IPVFGSDELA RLTEAFNLML RALAESRERQ
241 ARLVTDAGHE LRTPLTSLRT NVELLMASMA PGAPRLPKQE MVDLRADVLA QIEELSTLVG
301 DLVDLSRGDA GEVVHEPVDM ADVVDRSLER VRRRRNDIHF DVEVIGWQVY GDTAGLSRMA
361 LNLMDNAAKW SPPGGHVGVR LSQLDASHAE LVVSDRGPGI PVQERRLVFE RFYRSASARA
421 LPGSGLGLAI VKQVVLNHGG LLRIEDTDPG GQPPGTSIYV LLPGRRMPIP QLPGATAGAR
481 STDIENSRGS ANVISVESQS TRAT
//