LOCUS       SIT99569.1               553 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            GLUCOSE-6-PHOSPHATE ISOMERASE PGI (GPI) (PHOSPHOGLUCOSE
            ISOMERASE) (PHOSPHOHEXOSE ISOMERASE) (PHI) protein.
ACCESSION   LT708304-981
PROTEIN_ID  SIT99569.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="pgi"
                     /locus_tag="BQ2027_MB0971C"
                     /note="Mb0971c, pgi, len: 553 aa. Equivalent to Rv0946c,
                     len: 553 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100% identity in 553 aa overlap). Probable pgi,
                     glucose-6-phosphate isomerase (EC 5.3.1.9), equivalent to
                     NP_301236.1|NC_002677 glucose-6-phosphate isomerase from
                     Mycobacterium leprae (554 aa); and P96803|G6PI_MYCSM
                     GLUCOSE-6-PHOSPHATE ISOMERASE from Mycobacterium smegmatis
                     (442 aa). Also highly similar to others e.g. T36015
                     glucose-6-phosphate isomerase from Streptomyces coelicolor
                     (551 aa); P11537|G6PI_ECOLI|GPI glucose-6-phosphate
                     isomerase from Escherichia coli strains K12 and O157:H7
                     (549 aa), FASTA scores: opt: 1779, E(): 0, (51.4% identity
                     in 554 aa overlap); etc. Contains PS00765 Phosphoglucose
                     isomerase signature 1, and PS00174 Phosphoglucose
                     isomerase signature 2. BELONGS TO THE GPI FAMILY. Protein
                     product from Mb0971c detected using shotgun mass
                     spectrometry. Mb0971c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:P64193"
                     /db_xref="InterPro:IPR001672"
                     /db_xref="InterPro:IPR018189"
                     /db_xref="InterPro:IPR023096"
                     /db_xref="InterPro:IPR035476"
                     /db_xref="InterPro:IPR035482"
                     /db_xref="UniProtKB/Swiss-Prot:P64193"
BEGIN
        1 MTSAPIPDIT ATPAWDALRR HHDQIGNTHL RQFFADDPGR GRELTVSVGD LYIDYSKHRV
       61 TRETLALLID LARTAHLEER RDQMFAGVHI NTSEDRAVLH TALRLPRDAE LVVDGQDVVT
      121 DVHAVLDAMG AFTDRLRSGE WTGATGKRIS TVVNIGIGGS DLGPVMVYQA LRHYADAGIS
      181 ARFVSNVDPA DLIATLADLD PATTLFIVAS KTFSTLETLT NATAARRWLT DALGDAAVSR
      241 HFVAVSTNKR LVDDFGINTD NMFGFWDWVG GRYSVDSAIG LSLMTVIGRD AFADFLAGFH
      301 IIDRHFATAP LESNAPVLLG LIGLWYSNFF GAQSRTVLPY SNDLSRFPAY LQQLTMESNG
      361 KSTRADGSPV SADTGEIFWG EPGTNGQHAF YQLLHQGTRL VPADFIGFAQ PLDDLPTAEG
      421 TGSMHDLLMS NFFAQTQVLA FGKTAEEIAA DGTPAHVVAH KVMPGNRPST SILASRLTPS
      481 VLGQLIALYE HQVFTEGVVW GIDSFDQWGV ELGKTQAKAL LPVITGAGSP PPQSDSSTDG
      541 LVRRYRTERG RAG
//