LOCUS SIT99567.1 158 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE (FAPY-DNA GLYCOSYLASE) protein. ACCESSION LT708304-979 PROTEIN_ID SIT99567.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB0969" /note="Mb0969, -, len: 158 aa. Equivalent to Rv0944, len: 158 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 158 aa overlap). Possible formamidopyrimidine-DNA glycosylase (EC 3.2.2.23), similar to C-terminus of formamidopyrimidine-DNA glycosylases e.g. CAB63194.1|AL133469 putative formamidopyrimidine-DNA glycosylase from Streptomyces coelicolor (287 aa); FPG_LACLA|NP_266509.1|NC_002662 formamidopyrimidine-DNA glycosylase (EC 3.2.2.23) from Lactococcus lactis subsp. lactis (273 aa), FASTA scores: opt: 246, E(): 2.4e-09, (28.9% identity in 142 aa overlap); O50606|FPG_THETH|MUTM|FPG FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE from Thermus thermophilus (267 aa); etc. Also similar to C-termini of endonucleases or DNA glycosylases of Mycobacterium tuberculosis e.g. Rv3297, Rv2464c, Rv2924c. MAY BE BELONG TO THE FPG FAMILY. Mb0969 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:A0A1R3XWW9" /db_xref="InterPro:IPR000214" /db_xref="InterPro:IPR010663" /db_xref="InterPro:IPR010979" /db_xref="InterPro:IPR015886" /db_xref="UniProtKB/TrEMBL:A0A1R3XWW9" BEGIN 1 MAGTPQPRAL GPDALDVSTD DLAGLLAGNT GRIKTVITDQ KVIAGIGNAY SDEILHVAKI 61 SPFATAGKLS GAQLTCLHEA MASVLSDAVR RSVGQGAAML KGEKRSGLRV HARTGLPCPV 121 CGDTVREVSF ADKSFQYCPT CQTGGKALAD RRMSRLLK //